| pubmed-article:19875205 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19875205 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:19875205 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:19875205 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:19875205 | lifeskim:mentions | umls-concept:C0599740 | lld:lifeskim |
| pubmed-article:19875205 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19875205 | pubmed:dateCreated | 2010-2-1 | lld:pubmed |
| pubmed-article:19875205 | pubmed:abstractText | Sigma-1 receptors are involved in numerous pathological dysfunctions and the synthesis of selective ligands is of interest. We identified a fused tetrahydroisoquinoline-hydantoin (Tic-hydantoin) structure with high affinity and selectivity for these receptors. We report here our efforts towards the pharmacomodulation of this substructure, the synthesis of 9 analogs with stereochemistry inversion, opening of isoquinoline ring, removal of isoquinoline nitrogen, replacement of isoquinoline by pyridine, of Tic-hydantoin moiety by quinazolinedione heterocycle. All these analogs provided a loss in the affinity for the sigma-1 receptor. The present work underlines the real importance of the Tic-hydantoin moiety for the obtainment of high affinity ligands. | lld:pubmed |
| pubmed-article:19875205 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19875205 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19875205 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19875205 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19875205 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:VaccherClaude... | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:FoulonCatheri... | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:JacquemardUlr... | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:MelnykPatrici... | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:MoussetDebora... | lld:pubmed |
| pubmed-article:19875205 | pubmed:author | pubmed-author:ToussaintMari... | lld:pubmed |
| pubmed-article:19875205 | pubmed:copyrightInfo | Copyright 2009 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:19875205 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19875205 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:19875205 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19875205 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19875205 | pubmed:pagination | 256-63 | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:meshHeading | pubmed-meshheading:19875205... | lld:pubmed |
| pubmed-article:19875205 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19875205 | pubmed:articleTitle | Sigma-1 ligands: Tic-hydantoin as a key pharmacophore. | lld:pubmed |
| pubmed-article:19875205 | pubmed:affiliation | UMR CNRS 8161-Université Lille Nord de France-Institut Pasteur de Lille, 1 rue du Professeur Calmette, B.P. 447, 59021 Lille cedex, France. | lld:pubmed |
| pubmed-article:19875205 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19875205 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19875205 | lld:chembl |
