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| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0032339 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0206255 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C1539358 | lld:lifeskim |
| pubmed-article:19859560 | lifeskim:mentions | umls-concept:C0016910 | lld:lifeskim |
| pubmed-article:19859560 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19859560 | pubmed:dateCreated | 2009-10-27 | lld:pubmed |
| pubmed-article:19859560 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19859560 | pubmed:abstractText | The malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant Systems are in development for this vaccine, an oil-in water emulsion--based formulation (AS02) and a formulation based on liposomes (AS01). METHODS & PRINCIPAL FINDINGS: In this Phase II, double-blind study (NCT00307021), 180 healthy Gabonese children aged 18 months to 4 years were randomized to receive either RTS,S/AS01(E) or RTS,S/AS02(D), on a 0-1-2 month vaccination schedule. The children were followed-up daily for six days after each vaccination and monthly for 14 months. Blood samples were collected at 4 time-points. Both vaccines were well tolerated. Safety parameters were distributed similarly between the two groups. Both vaccines elicited a strong specific immune response after Doses 2 and 3 with a ratio of anti-CS GMT titers (AS02(D)/AS01(E)) of 0.88 (95% CI: 0.68-1.15) post-Dose 3. After Doses 2 and 3 of experimental vaccines, anti-CS and anti-HBs antibody GMTs were higher in children who had been previously vaccinated with at least one dose of hepatitis B vaccine compared to those not previously vaccinated. | lld:pubmed |
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| pubmed-article:19859560 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19859560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19859560 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19859560 | pubmed:author | pubmed-author:LellBertrandB | lld:pubmed |
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| pubmed-article:19859560 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19859560 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19859560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19859560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19859560 | pubmed:pagination | e7611 | lld:pubmed |
| pubmed-article:19859560 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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| pubmed-article:19859560 | pubmed:meshHeading | pubmed-meshheading:19859560... | lld:pubmed |
| pubmed-article:19859560 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19859560 | pubmed:articleTitle | A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon. | lld:pubmed |
| pubmed-article:19859560 | pubmed:affiliation | Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon. | lld:pubmed |
| pubmed-article:19859560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19859560 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:19859560 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19859560 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
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