| pubmed-article:19858195 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0021948 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0016786 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0085249 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C1879647 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19858195 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19858195 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:19858195 | pubmed:dateCreated | 2009-12-21 | lld:pubmed |
| pubmed-article:19858195 | pubmed:abstractText | Galectin CGL2 from the ink cap mushroom Coprinopsis cinerea displays toxicity toward the model nematode Caenorhabditis elegans. A mutation in a putative glycosyltransferase-encoding gene resulted in a CGL2-resistant C. elegans strain characterized by N-glycans lacking the beta1,4-galactoside linked to the alpha1,6-linked core fucose. Expression of the corresponding GALT-1 protein in insect cells was used to demonstrate a manganese-dependent galactosyltransferase activity. In vitro, the GALT-1 enzyme showed strong selectivity for acceptors with alpha1,6-linked N-glycan core fucosides and required Golgi- dependent modifications on the oligosaccharide antennae for optimal synthesis of the Gal-beta1,4-fucose structure. Phylogenetic analysis of the GALT-1 protein sequence identified a novel glycosyltransferase family (GT92) with members widespread among eukarya but absent in mammals. | lld:pubmed |
| pubmed-article:19858195 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19858195 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19858195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19858195 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19858195 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19858195 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:HennetThierry... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:AebiMarkusM | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:HengartnerMic... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:WilsonIain... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:HenrissatBern... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:KünzlerMarkus... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:TitzAlexander... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:Razzazi-Fazel... | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:FanYao-YunYY | lld:pubmed |
| pubmed-article:19858195 | pubmed:author | pubmed-author:ButschiAlexA | lld:pubmed |
| pubmed-article:19858195 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19858195 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:19858195 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:19858195 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19858195 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19858195 | pubmed:pagination | 36223-33 | lld:pubmed |
| pubmed-article:19858195 | pubmed:dateRevised | 2011-4-6 | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:meshHeading | pubmed-meshheading:19858195... | lld:pubmed |
| pubmed-article:19858195 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19858195 | pubmed:articleTitle | Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. | lld:pubmed |
| pubmed-article:19858195 | pubmed:affiliation | Institute of Microbiology, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland. | lld:pubmed |
| pubmed-article:19858195 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19858195 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:187430 | entrezgene:pubmed | pubmed-article:19858195 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19858195 | lld:pubmed |
