| pubmed-article:19857905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0020963 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0762640 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C1336681 | lld:lifeskim |
| pubmed-article:19857905 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:19857905 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:19857905 | pubmed:dateCreated | 2009-11-27 | lld:pubmed |
| pubmed-article:19857905 | pubmed:abstractText | Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine, and the functional TSLP receptor (TSLPR) consists of a common IL-7 receptor alpha chain (IL-7Ralpha) and TSLP-specific gamma receptor chain (TSLPR-gamma). It has been demonstrated that TSLP plays an important role in the Th2 bias and regulatory T cell expansion of immune response and tolerance. A successful pregnancy, especially in the early phase, demonstrates features of a Th2 immune response and requires CD4(+)Foxp3(+) regulatory T cell expansion. We have found recently that TSLP-instructed decidual dendritic cells (dDCs) promote decidual CD4(+) T cells to produce Th2-type cytokines including IL-10, which is believed to be a key player in maternal-fetal tolerance. Phenotypic analyses have shown that the expanded cells are mainly CD4(+) Th2 cells and Foxp3(+) regulatory T cells. Our findings show that trophoblasts secrete TSLP that is able to instruct the dDCs to induce CD4(+) Th2 cell and Foxp3(+) regulatory T cell differentiation in decidual CD4(+) T cells. | lld:pubmed |
| pubmed-article:19857905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19857905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19857905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19857905 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19857905 | pubmed:issn | 1872-7603 | lld:pubmed |
| pubmed-article:19857905 | pubmed:author | pubmed-author:GuoPei-FenPF | lld:pubmed |
| pubmed-article:19857905 | pubmed:author | pubmed-author:LiDa-JinDJ | lld:pubmed |
| pubmed-article:19857905 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19857905 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:19857905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19857905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19857905 | pubmed:pagination | 106-8 | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
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| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:meshHeading | pubmed-meshheading:19857905... | lld:pubmed |
| pubmed-article:19857905 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19857905 | pubmed:articleTitle | The regulatory role of thymic stromal lymphopoietin (TSLP) in maternal-fetal immune tolerance during early human pregnancy. | lld:pubmed |
| pubmed-article:19857905 | pubmed:affiliation | Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, China. djli@shmu.edu.cn | lld:pubmed |
| pubmed-article:19857905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19857905 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:85480 | entrezgene:pubmed | pubmed-article:19857905 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19857905 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19857905 | lld:pubmed |
