| pubmed-article:19853379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0016658 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0458219 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C0234194 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C1826435 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:19853379 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:19853379 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:19853379 | pubmed:dateCreated | 2009-11-25 | lld:pubmed |
| pubmed-article:19853379 | pubmed:abstractText | Tibia fracture followed by limb immobilization in rats evokes nociceptive and vascular changes resembling complex regional pain syndrome type I (CRPS I). Previously we observed that substance P (SP) and interleukin-1beta (IL-1beta) signaling contribute to chronic regional nociceptive sensitization in this model. It is known that inflammasome multi-protein complexes containing caspase-1 and NALP1 are involved in the activation of the IL-1beta family of pro-nociceptive cytokines expressed in skin and other tissues. Therefore, we hypothesized that SP activated inflammasomes might contribute to mechanical allodynia after fracture. Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia. Collectively, these data suggest that NALP1 containing inflammasomes activated by NK1 receptors are expressed in keratinocytes and contribute to post-traumatic regional nociceptive sensitization. These findings highlight the possible importance of neuro-cutaneous signaling and innate immunity mechanisms in the development of CRPS. | lld:pubmed |
| pubmed-article:19853379 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19853379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19853379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19853379 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19853379 | pubmed:issn | 1872-6623 | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:KingeryWade... | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:ClarkJ... | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:WeiTzupingT | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:LiWen-WuWW | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:GuoTian-ZhiTZ | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:ShiXiaoyouX | lld:pubmed |
| pubmed-article:19853379 | pubmed:author | pubmed-author:LiangDeyongD | lld:pubmed |
| pubmed-article:19853379 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19853379 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19853379 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:19853379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19853379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19853379 | pubmed:pagination | 277-86 | lld:pubmed |
| pubmed-article:19853379 | pubmed:dateRevised | 2011-3-29 | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:meshHeading | pubmed-meshheading:19853379... | lld:pubmed |
| pubmed-article:19853379 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19853379 | pubmed:articleTitle | The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. | lld:pubmed |
| pubmed-article:19853379 | pubmed:affiliation | Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. | lld:pubmed |
| pubmed-article:19853379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19853379 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19853379 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:25166 | entrezgene:pubmed | pubmed-article:19853379 | lld:entrezgene |
| entrez-gene:29197 | entrezgene:pubmed | pubmed-article:19853379 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19853379 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19853379 | lld:pubmed |
