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| pubmed-article:1985116 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1985116 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1985116 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1985116 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1985116 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1985116 | pubmed:dateCreated | 1991-2-1 | lld:pubmed |
| pubmed-article:1985116 | pubmed:abstractText | Freshly isolated B lymphocytes from patients infected with human immunodeficiency virus (HIV), in contrast to B cells from normal controls, were shown to induce viral expression in two cell lines: ACH-2, a T cell line, and U1, a promonocytic cell line, which are chronically infected with HIV, as well as in autologous T cells. In 10 out of 10 HIV-infected individuals with hypergammaglobulinemia, spontaneous HIV-inductive capacity was found with highly purified peripheral blood B cells, whereas peripheral blood or tonsillar B cells from six healthy, HIV-negative donors did not induce HIV expression unless the cells were stimulated in vitro. The induction of HIV expression was observed in direct coculture experiments of B lymphocytes and HIV-infected cells, and could also be mediated by supernatants from cultures of B cells. Significantly higher amounts of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were detected in the B cell culture supernatants from HIV-infected patients with hypergammaglobulinemia (IL-6: mean = 536 pg/ml; TNF-alpha: mean = 493 pg/ml), as compared with normal uninfected controls (IL-6: mean = 18 pg/ml; TNF-alpha: mean = 23 pg/ml). Antibodies against these cytokines abolished the HIV-inductive capacity of B cells. We conclude that in vivo activated B cells in HIV-infected individuals can upregulate the expression of virus in infected cells by secreting cytokines such as TNF-alpha and IL-6, and, therefore, may play a role in the progression of HIV infection. | lld:pubmed |
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| pubmed-article:1985116 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1985116 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1985116 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1985116 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1985116 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1985116 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1985116 | pubmed:author | pubmed-author:FauciA SAS | lld:pubmed |
| pubmed-article:1985116 | pubmed:author | pubmed-author:PoliGG | lld:pubmed |
| pubmed-article:1985116 | pubmed:author | pubmed-author:KehrlJ HJH | lld:pubmed |
| pubmed-article:1985116 | pubmed:author | pubmed-author:RieckmannPP | lld:pubmed |
| pubmed-article:1985116 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1985116 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1985116 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:1985116 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1985116 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1985116 | pubmed:pagination | 1-5 | lld:pubmed |
| pubmed-article:1985116 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1985116 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1985116 | pubmed:articleTitle | Activated B lymphocytes from human immunodeficiency virus-infected individuals induce virus expression in infected T cells and a promonocytic cell line, U1. | lld:pubmed |
| pubmed-article:1985116 | pubmed:affiliation | Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1985116 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1985116 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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