| pubmed-article:19846517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C0025011 | lld:lifeskim |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C0015980 | lld:lifeskim |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:19846517 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:19846517 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19846517 | pubmed:dateCreated | 2009-12-16 | lld:pubmed |
| pubmed-article:19846517 | pubmed:abstractText | The measles virus P gene products V and C antagonize the host interferon (IFN) response, blocking both IFN signaling and production. Using Moraten vaccine strain-derived measles virus and isogenic mutants deficient for either V or C protein production (V(ko) and C(ko), respectively), we observed that the C(ko) virus was a potent inducer of IFN-beta, while induction by V(ko) virus was an order of magnitude lower than that by the C(ko) virus. The parental recombinant Moraten virus did not significantly induce IFN-beta. The enhanced IFN-inducing capacity of the C(ko) virus correlated with an enhanced activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and ATF-2 in C(ko)-infected compared to V(ko) or parental virus-infected cells. Furthermore, protein kinase PKR and mitochondrial adapter IPS-1 were required for maximal C(ko)-mediated IFN-beta induction, which correlated with the PKR-mediated enhancement of mitogen-activated protein kinase and NF-kappaB activation. Our results reveal multiple consequences of C protein expression and document an important function for PKR as an enhancer of IFN-beta induction during measles virus infection. | lld:pubmed |
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| pubmed-article:19846517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19846517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19846517 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19846517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19846517 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19846517 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:ZhangPingP | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:CattaneoRober... | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:SamuelCharles... | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:DevauxPatrici... | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:TothAnn MAM | lld:pubmed |
| pubmed-article:19846517 | pubmed:author | pubmed-author:McAllisterChr... | lld:pubmed |
| pubmed-article:19846517 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19846517 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:19846517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19846517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19846517 | pubmed:pagination | 380-6 | lld:pubmed |
| pubmed-article:19846517 | pubmed:dateRevised | 2011-5-9 | lld:pubmed |
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| pubmed-article:19846517 | pubmed:meshHeading | pubmed-meshheading:19846517... | lld:pubmed |
| pubmed-article:19846517 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19846517 | pubmed:articleTitle | Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus. | lld:pubmed |
| pubmed-article:19846517 | pubmed:affiliation | Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. | lld:pubmed |
| pubmed-article:19846517 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19846517 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
