| pubmed-article:1984603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1984603 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:1984603 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1984603 | lifeskim:mentions | umls-concept:C1145670 | lld:lifeskim |
| pubmed-article:1984603 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:1984603 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1984603 | pubmed:dateCreated | 1991-1-30 | lld:pubmed |
| pubmed-article:1984603 | pubmed:abstractText | Surfactant inactivation has been shown to be a significant factor in animal models of lung injury and may also be important in some forms of respiratory failure in full-term newborns. Fourteen full-term newborns with respiratory failure associated with pneumonia (7 patients) and meconium aspiration syndrome (7 patients) were treated with 90 mg/kg of a calf lung surfactant extract, given intratracheally up to every 6 hours for a maximum of four doses. The group mean fraction of inspired oxygen (FI02) before treatment was 0.99 +/- 0.01 SEM, and the mean airway pressure (MAP) was 14.6 +/- 1.0 cm H2O. Patients showed significant improvement in oxygenation after initial surfactant treatment, with the arterial-alveolar oxygenation ratio (a/A ratio) rising from 0.09 +/- 0.01 before surfactant treatment to 0.22 +/- 0.05 by 15 minutes (P = .03) and remaining improved for 6 hours. The oxygenation index, incorporating MAP as well as oxygen variables, also improved significantly from 26.2 +/- 3.1 to 11.2 +/- 1.7 at 15 minutes (P less than .001), with improvement sustained for more than 6 hours. Chest radiographs were blindly scored from 0 (normal) to 5 (severe opacification), and these improved with marginal significance after initial surfactant treatment (from 2.9 +/- 0.2 to 2.5 +/- 0.2, P = .05).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1984603 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1984603 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1984603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1984603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1984603 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1984603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1984603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1984603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1984603 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1984603 | pubmed:issn | 0031-4005 | lld:pubmed |
| pubmed-article:1984603 | pubmed:author | pubmed-author:DavisJ MJM | lld:pubmed |
| pubmed-article:1984603 | pubmed:author | pubmed-author:ShapiroD LDL | lld:pubmed |
| pubmed-article:1984603 | pubmed:author | pubmed-author:NotterR HRH | lld:pubmed |
| pubmed-article:1984603 | pubmed:author | pubmed-author:KendigJ WJW | lld:pubmed |
| pubmed-article:1984603 | pubmed:author | pubmed-author:AutenR LRL | lld:pubmed |
| pubmed-article:1984603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1984603 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1984603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1984603 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1984603 | pubmed:pagination | 101-7 | lld:pubmed |
| pubmed-article:1984603 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1984603 | pubmed:meshHeading | pubmed-meshheading:1984603-... | lld:pubmed |
| pubmed-article:1984603 | pubmed:meshHeading | pubmed-meshheading:1984603-... | lld:pubmed |
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| pubmed-article:1984603 | pubmed:meshHeading | pubmed-meshheading:1984603-... | lld:pubmed |
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| pubmed-article:1984603 | pubmed:meshHeading | pubmed-meshheading:1984603-... | lld:pubmed |
| pubmed-article:1984603 | pubmed:meshHeading | pubmed-meshheading:1984603-... | lld:pubmed |
| pubmed-article:1984603 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1984603 | pubmed:articleTitle | Surfactant treatment of full-term newborns with respiratory failure. | lld:pubmed |
| pubmed-article:1984603 | pubmed:affiliation | Department of Pediatrics (Neonatology), University of Rochester School of Medicine, New York 14642. | lld:pubmed |
| pubmed-article:1984603 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1984603 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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