| pubmed-article:19830741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C1333568 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0017279 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0297523 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:19830741 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:19830741 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19830741 | pubmed:dateCreated | 2010-1-4 | lld:pubmed |
| pubmed-article:19830741 | pubmed:abstractText | DC present exogenous proteins to MHC class I-restricted CD8+ T cells. This function does not require endogenous antigen synthesis within DC, providing the potential to elicit CD8+ T-cell responses to immune complexes, inactivated microbes, dying cells, and proteins such as OVA. In mice, the CD8+ or DEC-205+ DC are specialized for cross-presentation, and this subset can be increased 10-fold in numbers following Fms-like tyrosine kinase 3 ligand (Flt3L) treatment in vivo. Therefore, we studied cross-presentation by abundant Flt3L DC using HIV gag protein. When enriched by positive selection with anti-CD11c beads, cells from Flt3L mice are not only more abundant but are also more highly enriched in CD11chigh DC, particularly the DEC-205+ subset. DC cross-present HIV gag to primed CD8+ T cells, but when the antigen is delivered within an antibody to DEC-205 receptor, cross-presentation becomes 100-fold more efficient than non-targeted antigen. This finding requires gag to be engineered into anti-DEC antibody, not just mixed with antibody. Flt3L DC are a valuable tool to study cross-presentation, since their use overcomes the obstacle posed by the low number of cross-presenting DC in the steady state. These findings support future experiments to use Flt3L to enhance presentation of DC-targeted vaccines. | lld:pubmed |
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| pubmed-article:19830741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19830741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19830741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19830741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19830741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19830741 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19830741 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:SteinmanRalph... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:HuangYaoxingY | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:ShimeliovichI... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:ParkChae... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:TrumpfhellerC... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:BozzaccoLeoni... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:LonghiMaria... | lld:pubmed |
| pubmed-article:19830741 | pubmed:author | pubmed-author:SchauerJoseph... | lld:pubmed |
| pubmed-article:19830741 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19830741 | pubmed:volume | 40 | lld:pubmed |
