Linked Life Data

19830702

Source:http://linkedlifedata.com/resource/pubmed/id/19830702

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pubmed-article:19830702pubmed:abstractTextEmerging evidence has shown that GSK3beta plays a pivotal role in regulating the specification of axons and dendrites. Our previous study has shown a novel GSK3beta interaction protein (GSKIP) able to negatively regulate GSK3beta in Wnt signaling pathway. To further characterize how GSKIP functions in neurons, human neuroblastoma SH-SY5Y cells treated with retinoic acid (RA) to differentiate to neuron-like cells was used as a model. Overexpression of GSKIP prevents neurite outgrowth in SH-SY5Y cells. GSKIP may affect GSK3beta activity on neurite outgrowth by inhibiting the specific phosphorylation of tau (ser396). GSKIP also increases beta-catenin in the nucleus and raises the level of cyclin D1 to promote cell-cycle progression in SH-SY5Y cells. Additionally, overexpression of GSKIP downregulates N-cadherin expression, resulting in decreased recruitment of beta-catenin. Moreover, depletion of beta-catenin by small interfering RNA, neurite outgrowth is blocked in SH-SY5Y cells. Altogether, we propose a model to show that GSKIP regulates the functional interplay of the GSK3beta/beta-catenin, beta-catenin/cyclin D1, and beta-catenin/N-cadherin pool during RA signaling in SH-SY5Y cells.lld:pubmed
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pubmed-article:19830702pubmed:authorpubmed-author:HowngShen-Lon...lld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:HsuChing-MeiC...lld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:WangChihueiClld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:HongYi-RenYRlld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:HwangChi-Chin...lld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:LinChing-Chih...lld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:HsuChia-YiCYlld:pubmed
pubmed-article:19830702pubmed:authorpubmed-author:ChouChia-HuaC...lld:pubmed
pubmed-article:19830702pubmed:copyrightInfo(c) 2009 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:19830702pubmed:dateRevised2011-11-2lld:pubmed
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pubmed-article:19830702pubmed:year2009lld:pubmed
pubmed-article:19830702pubmed:articleTitleGSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells.lld:pubmed
pubmed-article:19830702pubmed:affiliationDepartment of Biochemistry, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.lld:pubmed
pubmed-article:19830702pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19830702pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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