| pubmed-article:19829160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0034700 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0002844 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19829160 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:19829160 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:19829160 | pubmed:dateCreated | 2009-11-6 | lld:pubmed |
| pubmed-article:19829160 | pubmed:abstractText | Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble beta-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk. | lld:pubmed |
| pubmed-article:19829160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19829160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19829160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19829160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19829160 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19829160 | pubmed:issn | 1473-558X | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:Paul MurphyMM | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:StanczykFrank... | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:ChangLillyL | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:PikeChristian... | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:RosarioEmily... | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:CarrollJenna... | lld:pubmed |
| pubmed-article:19829160 | pubmed:author | pubmed-author:BeckettTina... | lld:pubmed |
| pubmed-article:19829160 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19829160 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:19829160 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:19829160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19829160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19829160 | pubmed:pagination | 1534-7 | lld:pubmed |
| pubmed-article:19829160 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:meshHeading | pubmed-meshheading:19829160... | lld:pubmed |
| pubmed-article:19829160 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19829160 | pubmed:articleTitle | Age-related changes in serum and brain levels of androgens in male Brown Norway rats. | lld:pubmed |
| pubmed-article:19829160 | pubmed:affiliation | Neuroscience Graduate Program, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. | lld:pubmed |
| pubmed-article:19829160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19829160 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:54226 | entrezgene:pubmed | pubmed-article:19829160 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19829160 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19829160 | lld:pubmed |
