Linked Life Data

19828700

Source:http://linkedlifedata.com/resource/pubmed/id/19828700

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pubmed-article:19828700pubmed:abstractTextHaploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be improved by facilitation of thymic immigration, known to require precommitment of CD34(+) cells. We demonstrate that Delta-like ligand-mediated predifferentiation of mobilized CD34(+) cells in vitro results in a population of thymocyte-like cells arrested at a T/natural killer (NK)-cell progenitor stage. On intrahepatic transfer to Rag2(-/-)gamma(c)(-/-) mice, these cells selectively home to the thymus and differentiate toward surface T-cell receptor-alphabeta(+) mature T cells considerably faster than animals transplanted with noncultured CD34(+) cells. This finding creates the opportunity to develop an early T-cell reconstitution therapy to combine with HSCT.lld:pubmed
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pubmed-article:19828700pubmed:articleTitleIn vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus.lld:pubmed
pubmed-article:19828700pubmed:affiliationDepartment of Internal Medicine, Division of Haematology, Maastricht University Medical Center, Maastricht, The Netherlands;lld:pubmed
pubmed-article:19828700pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19828700pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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