| pubmed-article:19812053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0052189 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0683150 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0441994 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C1412475 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:19812053 | lifeskim:mentions | umls-concept:C1637833 | lld:lifeskim |
| pubmed-article:19812053 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19812053 | pubmed:dateCreated | 2010-3-10 | lld:pubmed |
| pubmed-article:19812053 | pubmed:abstractText | Apolipoprotein (apo) C-I is a constituent of chylomicrons, very low density lipoprotein, and high density lipoprotein. The role of apo C-I in human metabolism is incompletely defined. We took advantage of a naturally occurring amino acid polymorphism that is present in aboriginal North Americans, namely apo C-I T45S. We assessed the hypothesis that metabolic traits, including obesity-related and lipoprotein-related traits, would differ between carriers and noncarriers of apo C-I T45S. A genotyping assay was developed for APOC1 T45S and genotypes were determined in a sample of 410 Canadian Oji-Cree subjects. The allele frequency of the apo C-I S45 allele was approximately 8% in this sample. We observed the apo C-I S45 allele was significantly associated with 1) lower percent body fat (P < 0.05), 2) lower waist circumference (P = 0.058), 3) lower serum leptin levels (P < 0.05), and 4) lower plasma apo C-I levels (P < 0.0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels. | lld:pubmed |
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| pubmed-article:19812053 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19812053 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19812053 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19812053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19812053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19812053 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19812053 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:HensonT ATA | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:ConnellyPhili... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:HanleyAnthony... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:HarrisStewart... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:HegeleRobert... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:ZinmanBernard... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:HuffMurray... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:BanMatthew... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:PollexRebecca... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:MamakeesickMa... | lld:pubmed |
| pubmed-article:19812053 | pubmed:author | pubmed-author:LahiryPiyaP | lld:pubmed |
| pubmed-article:19812053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19812053 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:19812053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19812053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19812053 | pubmed:pagination | 843-8 | lld:pubmed |
| pubmed-article:19812053 | pubmed:dateRevised | 2011-7-27 | lld:pubmed |
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