| pubmed-article:19811296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0445550 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19811296 | lifeskim:mentions | umls-concept:C0205184 | lld:lifeskim |
| pubmed-article:19811296 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19811296 | pubmed:dateCreated | 2009-10-8 | lld:pubmed |
| pubmed-article:19811296 | pubmed:abstractText | Low dose radiotherapy (LD-RT) is known to exert an anti-inflammatory effect. The underlying molecular mechanisms, however, are still a matter of actual research. We have recently shown that LD-RT of stimulated EA.hy.926 endothelial cells (EC) resulted in a biphasic DNA-binding and transcriptional activity of NF-kappaB in parallel with a biphasic course of leukocyte adhesion. Here we report, that following low dose X-irradiation, an increased activator protein 1 (AP-1) DNA-binding activity was observed in EC with a first relative maximum at 0.3 Gy as analysed by electrophoretic mobility shift assay. AP-1 activity then decreased at doses between 0.5 and 1 Gy and subsequently increased again at 3 Gy. This biphasic profile was confirmed on the transcriptional level by an AP-1 specific chemoluminescence reporter assay. In conclusion, the discontinuous dose response of AP-1 activation may add a further facet to the plethora of mechanisms contributing to the anti-inflammatory efficacy of LD-RT. | lld:pubmed |
| pubmed-article:19811296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19811296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19811296 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19811296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19811296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19811296 | pubmed:month | May | lld:pubmed |
| pubmed-article:19811296 | pubmed:issn | 1607-842X | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:RödelFranzF | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:GaiplUdoU | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:HerrmannMarti... | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:RödelClausC | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:WeissChristia... | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:FreyBenjaminB | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:VollReinhardR | lld:pubmed |
| pubmed-article:19811296 | pubmed:author | pubmed-author:KeilholzLudwi... | lld:pubmed |
| pubmed-article:19811296 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19811296 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:19811296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19811296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19811296 | pubmed:pagination | 343-5 | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:meshHeading | pubmed-meshheading:19811296... | lld:pubmed |
| pubmed-article:19811296 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19811296 | pubmed:articleTitle | Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells. | lld:pubmed |
| pubmed-article:19811296 | pubmed:affiliation | Department of Radiotherapy and Oncology, University Hospital of Frankfurt, Frankfurt, Germany. franz.roedel@kgu.de | lld:pubmed |
| pubmed-article:19811296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19811296 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3725 | entrezgene:pubmed | pubmed-article:19811296 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19811296 | lld:entrezgene |
