| pubmed-article:19809157 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0009402 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0041361 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:19809157 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:19809157 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19809157 | pubmed:dateCreated | 2009-11-3 | lld:pubmed |
| pubmed-article:19809157 | pubmed:abstractText | Spontaneous antitumor T cell responses in cancer patients are strongly controlled by Tregs, and increased numbers of tumor-infiltrating Tregs correlate with reduced survival. However, the tumor antigens recognized by Tregs in cancer patients and the impact of these cells on tumor-specific T cell responses have not been systematically characterized. Here we used a broad panel of long synthetic peptides of defined tumor antigens and normal tissue antigens to exploit a newly developed method to identify and compare ex vivo the antigen specificities of Tregs with those of effector/memory T cells in peripheral blood of colorectal cancer patients and healthy subjects. Tregs in tumor patients were highly specific for a distinct set of only a few tumor antigens, suggesting that Tregs exert T cell suppression in an antigen-selective manner. Tumor-specific effector T cells were detectable in the majority of colorectal cancer patients but not in healthy individuals. We detected differences in the repertoires of antigens recognized by Tregs and effector/memory T cells in the majority of colorectal cancer patients. In addition, only effector/memory T cell responses against antigens recognized by Tregs strongly increased after Treg depletion. The selection of antigens according to preexisting T cell responses may improve the efficacy of future immunotherapies for cancer and autoimmune disease. | lld:pubmed |
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| pubmed-article:19809157 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19809157 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19809157 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19809157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19809157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19809157 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19809157 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19809157 | pubmed:issn | 1558-8238 | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:KhazaieKhasha... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:VlodavskyIsra... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:WeitzJürgenJ | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:ReissfelderCh... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:BeckhovePhili... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:KochMoritzM | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:JaegerDirkD | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:AntolovicDali... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:RahbariNuh... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:GeYingziY | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:BonertzAndrea... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:AignerMaximil... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:PietschDong-H... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:SchludeChrist... | lld:pubmed |
| pubmed-article:19809157 | pubmed:author | pubmed-author:JuengerSimone... | lld:pubmed |
| pubmed-article:19809157 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19809157 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:19809157 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19809157 | pubmed:authorsComplete | Y | lld:pubmed |
