| pubmed-article:19808254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19808254 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:19808254 | lifeskim:mentions | umls-concept:C2936411 | lld:lifeskim |
| pubmed-article:19808254 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:19808254 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:19808254 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19808254 | pubmed:dateCreated | 2009-10-27 | lld:pubmed |
| pubmed-article:19808254 | pubmed:abstractText | Interleukin (IL)-17-producing T helper (Th17) cells play a critical role in the pathophysiology of several autoimmune disorders. The differentiation of Th17 cells requires the simultaneous presence of an unusual combination of cytokines: IL-6, a proinflammatory cytokine, and transforming growth factor (TGF) beta, an antiinflammatory cytokine. However, the molecular mechanisms by which TGF-beta exerts its effects on Th17 cell differentiation remain elusive. We report that TGF-beta does not directly promote Th17 cell differentiation but instead acts indirectly by blocking expression of the transcription factors signal transducer and activator of transcription (STAT) 4 and GATA-3, thus preventing Th1 and Th2 cell differentiation. In contrast, TGF-beta had no effect on the expression of retinoic acid receptor-related orphan nuclear receptor gammat, a Th17-specific transcription factor. Interestingly, in Stat-6(-/-)T-bet(-/-) mice, which are unable to generate Th1 and Th2 cells, IL-6 alone was sufficient to induce robust differentiation of Th17 cells, whereas TGF-beta had no effect, suggesting that TGF-beta is dispensable for Th17 cell development. Consequently, BALB/c Stat-6(-/-)T-bet(-/-) mice, but not wild-type BALB/c mice, were highly susceptible to the development of experimental autoimmune encephalomyelitis, which could be blocked by anti-IL-17 antibodies but not by anti-TGF-beta antibodies. Collectively, these data provide evidence that TGF-beta is not directly required for the molecular orchestration of Th17 cell differentiation. | lld:pubmed |
| pubmed-article:19808254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19808254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19808254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19808254 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19808254 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:ZhaoXinX | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:Van KaerLucL | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:BothwellAlfre... | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:ZhangLiyingL | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:ShiYufangY | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:DasJyotiJ | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:RobertsArthur... | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:DasGobardhanG | lld:pubmed |
| pubmed-article:19808254 | pubmed:author | pubmed-author:RenGuangwenG | lld:pubmed |
| pubmed-article:19808254 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19808254 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:19808254 | pubmed:volume | 206 | lld:pubmed |
| pubmed-article:19808254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19808254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19808254 | pubmed:pagination | 2407-16 | lld:pubmed |
| pubmed-article:19808254 | pubmed:dateRevised | 2011-4-21 | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
| pubmed-article:19808254 | pubmed:meshHeading | pubmed-meshheading:19808254... | lld:pubmed |
