| pubmed-article:19805151 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19805151 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19805151 | lifeskim:mentions | umls-concept:C0232976 | lld:lifeskim |
| pubmed-article:19805151 | lifeskim:mentions | umls-concept:C1537684 | lld:lifeskim |
| pubmed-article:19805151 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:19805151 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:19805151 | pubmed:dateCreated | 2009-10-9 | lld:pubmed |
| pubmed-article:19805151 | pubmed:abstractText | Spermatogenesis can be divided into three stages: spermatogonial mitosis, meiosis of spermatocytes, and spermiogenesis. During spermiogenesis, spermatids undergo dramatic morphological changes including formation of a flagellum and chromosomal packaging and condensation of the nucleus into the sperm head. The genes regulating the latter processes are largely unknown. We previously discovered that a bi-functional gene, Spag16, is essential for spermatogenesis. SPAG16S, the 35 kDa, testis-specific isoform derived from the Spag16 gene, was found to bind to meiosis expressed gene 1 product (MEIG1), a protein originally thought to play a role in meiosis. We inactivated the Meig1 gene and, unexpectedly, found that Meig1 mutant male mice had no obvious defect in meiosis, but were sterile as a result of impaired spermatogenesis at the stage of elongation and condensation. Transmission electron microscopy revealed that the manchette, a microtubular organelle essential for sperm head and flagellar formation was disrupted in spermatids of MEIG1-deficient mice. We also found that MEIG1 associates with the Parkin co-regulated gene (PACRG) protein, and that testicular PACRG protein is reduced in MEIG1-deficient mice. PACRG is thought to play a key role in assembly of the axonemes/flagella and the reproductive phenotype of Pacrg-deficient mice mirrors that of the Meig1 mutant mice. Our findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis. | lld:pubmed |
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| pubmed-article:19805151 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19805151 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19805151 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19805151 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19805151 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19805151 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:HerrJohn CJC | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:StraussJerome... | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:JusticeMonica... | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:FlickingerCha... | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:ShenXueningX | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:EddyEdward... | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:ZhangZhibingZ | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:GudeDavid RDR | lld:pubmed |
| pubmed-article:19805151 | pubmed:author | pubmed-author:WilkinsonBonn... | lld:pubmed |
| pubmed-article:19805151 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19805151 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:19805151 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19805151 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19805151 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19805151 | pubmed:pagination | 17055-60 | lld:pubmed |
| pubmed-article:19805151 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
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