| pubmed-article:19805150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C1550594 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C1539588 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C1548760 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C1547300 | lld:lifeskim |
| pubmed-article:19805150 | lifeskim:mentions | umls-concept:C0580822 | lld:lifeskim |
| pubmed-article:19805150 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:19805150 | pubmed:dateCreated | 2009-10-9 | lld:pubmed |
| pubmed-article:19805150 | pubmed:abstractText | Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mouse brain tumor model induced by retroviral Ras expression on a p16(Ink4a)/p19(Arf)-deficient background. The NS-GFP system allowed us to monitor the differentiation process of normal neural stem/precursor cells by analyzing GFP fluorescence intensity. In tumor-bearing mice, despite the very high frequency of tumorigenic cells, we successfully identified the NS-GFP(+) cells as tumor-initiating cells (T-ICs). The clonal studies conclusively established that phenotypical heterogeneity can exist among the cells comprising a genetically homogeneous tumor, suggesting that this aggressive brain tumor follows the CSC model. Detailed analyses of the NS-GFP(+) brain tumor cells revealed that T-ICs showed activation of the receptor tyrosine kinase c-Met, which functions in tumor invasiveness. Thus, the NS-GFP system provides a powerful tool to elucidate stem cell biology in normal and malignant tissues. | lld:pubmed |
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| pubmed-article:19805150 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19805150 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19805150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19805150 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19805150 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:SayaHideyukiH | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:SawamotoKazun... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:OkanoHideyuki... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:SudaToshioT | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:OnoderaMasafu... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:OshimaMasanob... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:MatsumotoKuni... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:HiraoAtsushiA | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:HamadaJun-ich... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:AsanoMasahide... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:TanakaShingoS | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:NakaKazuhitoK | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:NakadaMitsuto... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:OhmuraMasakoM | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:OoshioTakakoT | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:HoshiiTakayuk... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:MuraguchiTeru... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:KinoshitaMasa... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:ShugoHaruhiko... | lld:pubmed |
| pubmed-article:19805150 | pubmed:author | pubmed-author:TamaseAkiraA | lld:pubmed |
| pubmed-article:19805150 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19805150 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:19805150 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19805150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19805150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19805150 | pubmed:pagination | 17163-8 | lld:pubmed |
| pubmed-article:19805150 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
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