rdf:type |
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0007634,
umls-concept:C0020792,
umls-concept:C0086860,
umls-concept:C0205250,
umls-concept:C0441655,
umls-concept:C0580822,
umls-concept:C1539588,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594
|
pubmed:issue |
40
|
pubmed:dateCreated |
2009-10-9
|
pubmed:abstractText |
Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mouse brain tumor model induced by retroviral Ras expression on a p16(Ink4a)/p19(Arf)-deficient background. The NS-GFP system allowed us to monitor the differentiation process of normal neural stem/precursor cells by analyzing GFP fluorescence intensity. In tumor-bearing mice, despite the very high frequency of tumorigenic cells, we successfully identified the NS-GFP(+) cells as tumor-initiating cells (T-ICs). The clonal studies conclusively established that phenotypical heterogeneity can exist among the cells comprising a genetically homogeneous tumor, suggesting that this aggressive brain tumor follows the CSC model. Detailed analyses of the NS-GFP(+) brain tumor cells revealed that T-ICs showed activation of the receptor tyrosine kinase c-Met, which functions in tumor invasiveness. Thus, the NS-GFP system provides a powerful tool to elucidate stem cell biology in normal and malignant tissues.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-10802656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-10871756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-11178865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-12086863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-12359767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-12464630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-12629218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-14555533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-14737120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-15549107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-16453287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-1689217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17000755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17046226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17062691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17133523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17260089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17463288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17618441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-17952057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-18077531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-18202660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-18613301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-18802033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-18829523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-19052619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-19122659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-19131997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-2531289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-8608856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-8620534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19805150-8660864
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AC133 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/nucleostemin protein, mouse
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1091-6490
|
pubmed:author |
pubmed-author:AsanoMasahideM,
pubmed-author:HamadaJun-ichiroJ,
pubmed-author:HiraoAtsushiA,
pubmed-author:HoshiiTakayukiT,
pubmed-author:KinoshitaMasashiM,
pubmed-author:MatsumotoKunioK,
pubmed-author:MuraguchiTeruyukiT,
pubmed-author:NakaKazuhitoK,
pubmed-author:NakadaMitsutoshiM,
pubmed-author:OhmuraMasakoM,
pubmed-author:OkanoHideyukiH,
pubmed-author:OnoderaMasafumiM,
pubmed-author:OoshioTakakoT,
pubmed-author:OshimaMasanobuM,
pubmed-author:SawamotoKazunobuK,
pubmed-author:SayaHideyukiH,
pubmed-author:ShugoHaruhikoH,
pubmed-author:SudaToshioT,
pubmed-author:TamaseAkiraA,
pubmed-author:TanakaShingoS
|
pubmed:issnType |
Electronic
|
pubmed:day |
6
|
pubmed:volume |
106
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
17163-8
|
pubmed:dateRevised |
2010-9-28
|
pubmed:meshHeading |
pubmed-meshheading:19805150-Animals,
pubmed-meshheading:19805150-Animals, Newborn,
pubmed-meshheading:19805150-Antigens, CD,
pubmed-meshheading:19805150-Brain Neoplasms,
pubmed-meshheading:19805150-Carrier Proteins,
pubmed-meshheading:19805150-Cell Differentiation,
pubmed-meshheading:19805150-Clone Cells,
pubmed-meshheading:19805150-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:19805150-Flow Cytometry,
pubmed-meshheading:19805150-Glycoproteins,
pubmed-meshheading:19805150-Green Fluorescent Proteins,
pubmed-meshheading:19805150-Immunohistochemistry,
pubmed-meshheading:19805150-Mice,
pubmed-meshheading:19805150-Mice, Inbred C57BL,
pubmed-meshheading:19805150-Mice, Knockout,
pubmed-meshheading:19805150-Mice, Transgenic,
pubmed-meshheading:19805150-Microscopy, Confocal,
pubmed-meshheading:19805150-Neoplastic Stem Cells,
pubmed-meshheading:19805150-Neurons,
pubmed-meshheading:19805150-Nuclear Proteins,
pubmed-meshheading:19805150-Peptides,
pubmed-meshheading:19805150-Promoter Regions, Genetic,
pubmed-meshheading:19805150-Proto-Oncogene Proteins c-met
|
pubmed:year |
2009
|
pubmed:articleTitle |
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.
|
pubmed:affiliation |
Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|