| pubmed-article:1980377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C1457887 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0677659 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0376180 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0014245 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0014869 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0028978 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0232552 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C1880019 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0205374 | lld:lifeskim |
| pubmed-article:1980377 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:1980377 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1980377 | pubmed:dateCreated | 1991-2-22 | lld:pubmed |
| pubmed-article:1980377 | pubmed:abstractText | To study the effects of sudden withdrawal of long-term maintenance therapy with omeprazole for up to 4 years, 14 patients with resistant reflux oesophagitis were asked to stop their treatment temporarily. Ten days after withdrawal median basal acid output had increased significantly (p = 0.01) from 0 (range, 0-1.18) on day 1 to 1.95 (range, 0-8.45) mmol/h on day 10. Median serum gastrin levels were raised during treatment with omeprazole but decreased significantly from 166 to 42 ng/l within the 10 days of the study (p = 0.01). The median integrated gastrin response after meal stimulation decreased significantly (p less than 0.001) from 758.6 ng/l on day 1 to 267.9 ng/l on day 10. On day 10 after withdrawal of omeprazole all patients had endoscopic and symptomatic evidence of recurrent oesophagitis. Reflux patients receiving maintenance treatment with omeprazole for up to 4 years showed prompt normalization of serum gastrin levels and return of gastric acid production within 10 days after stopping the treatment. Consequently, there was a fast recurrence of aggravation of reflux symptoms and oesophagitis. | lld:pubmed |
| pubmed-article:1980377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1980377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1980377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1980377 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1980377 | pubmed:issn | 0036-5521 | lld:pubmed |
| pubmed-article:1980377 | pubmed:author | pubmed-author:LamersC BCB | lld:pubmed |
| pubmed-article:1980377 | pubmed:author | pubmed-author:MeuwissenS... | lld:pubmed |
| pubmed-article:1980377 | pubmed:author | pubmed-author:Klinkenberg-K... | lld:pubmed |
| pubmed-article:1980377 | pubmed:author | pubmed-author:JansenJ BJB | lld:pubmed |
| pubmed-article:1980377 | pubmed:author | pubmed-author:NelisFF | lld:pubmed |
| pubmed-article:1980377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1980377 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:1980377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1980377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1980377 | pubmed:pagination | 1144-50 | lld:pubmed |
| pubmed-article:1980377 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:meshHeading | pubmed-meshheading:1980377-... | lld:pubmed |
| pubmed-article:1980377 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1980377 | pubmed:articleTitle | Temporary cessation of long-term maintenance treatment with omeprazole in patients with H2-receptor-antagonist-resistant reflux oesophagitis. Effects on symptoms, endoscopy, serum gastrin, and gastric acid output. | lld:pubmed |
| pubmed-article:1980377 | pubmed:affiliation | Dept. of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:1980377 | pubmed:publicationType | Journal Article | lld:pubmed |
