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pubmed-article:19796053pubmed:abstractTextPhosphodiesterase type 5 (PDE5) inhibitors ameliorate low urinary tract (LUT) symptoms in men with ED and symptomatic benign prostatic hyperplasia (BPH). PDE5 is highly expressed in rat and human bladder, where it regulates cyclic guanosine monophosphate (cGMP) degradation, muscle tone, and proliferation.lld:pubmed
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pubmed-article:19796053pubmed:articleTitleCharacterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.lld:pubmed
pubmed-article:19796053pubmed:affiliationAndrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy. m.maggi@dfc.unifi.itlld:pubmed
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