Linked Life Data

19795516

Source:http://linkedlifedata.com/resource/pubmed/id/19795516

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pubmed-article:19795516pubmed:dateCreated2009-10-28lld:pubmed
pubmed-article:19795516pubmed:abstractTextThe process of segmentation in vertebrates is described by a clock and wavefront model consisting of a Notch signal and an fibroblast growth factor-8 (FGF8) gradient, respectively. To further investigate the segmentation process, we screened gene expression profiles for downstream targets of the segmentation clock. The Rnd1 and Rnd3 GTP-binding proteins comprise a subgroup of the Rho GTPase family that show a specific expression pattern similar to the Notch signal component ESR5, suggesting an association between Rnd1/3 and the segmentation clock. Rnd1/3 expression patterns are disrupted by overexpression of dominant-negative or active forms of Notch signaling genes, and responds to the FGF inhibitor SU5402 by a posterior shift analogous to other segmentation-related genes, suggesting that Rnd1/3 expressions are regulated by the segmentation clock machinery. We also show that antisense morpholino oligonucleotides to Rnd1/3 inhibit somite segmentation and differentiation in Xenopus embryos. These results suggest that Rnd1/3 are required for Xenopus somitogenesis.lld:pubmed
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pubmed-article:19795516pubmed:authorpubmed-author:UenoNaotoNlld:pubmed
pubmed-article:19795516pubmed:authorpubmed-author:GodaTadahiroTlld:pubmed
pubmed-article:19795516pubmed:authorpubmed-author:TakagiChiyoClld:pubmed
pubmed-article:19795516pubmed:copyrightInfoCopyright 2009 Wiley-Liss, Inc.lld:pubmed
pubmed-article:19795516pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19795516pubmed:volume238lld:pubmed
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pubmed-article:19795516pubmed:articleTitleXenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation.lld:pubmed
pubmed-article:19795516pubmed:affiliationDivision of Morphogenesis, National Institute for Basic Biology, Myodaiji, Okazaki, Japan. tg8j@cms.mail.virginia.edulld:pubmed
pubmed-article:19795516pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19795516pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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