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pubmed-article:19783807pubmed:abstractTextWhen titanium is anodized by discharge in NaCl solution, both antimicrobial activity and osteoconductivity are conferred. The viability of adherent micro-organisms and cells on antimicrobial titanium remains uncertain. We hypothesized that a thin peroxidation barrier would efficiently destroy adherent bacteria, whereas adherent osteoblastic cells would be viable, since these cells adhere to the surface indirectly though serum proteins. The efficacy of antimicrobial titanium appears to be based on peroxidation, since peroxidation products were detected in parallel with the destruction of bacterial cell-surface structures. The peroxidation effect of antimicrobial titanium was confined to the surface within narrow limits. The viability of osteoblastic cells on the surface was strongly dependent on the presence of serum protein, whereas that of adherent Streptococcus mutans was not affected by the presence of serum proteins. Therefore, differences in the adherent systems used by bacteria and osteoblastic cells are important determinants of their viability on antimicrobial titanium.lld:pubmed
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pubmed-article:19783807pubmed:articleTitleMicro-organism and cell viability on antimicrobially modified titanium.lld:pubmed
pubmed-article:19783807pubmed:affiliationDepartment of Prosthodontics, Showa University School of Dentistry, 2-1-2, Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan.lld:pubmed
pubmed-article:19783807pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19783807pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed