| pubmed-article:1977810 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1977810 | lifeskim:mentions | umls-concept:C2717874 | lld:lifeskim |
| pubmed-article:1977810 | lifeskim:mentions | umls-concept:C0033618 | lld:lifeskim |
| pubmed-article:1977810 | lifeskim:mentions | umls-concept:C0077918 | lld:lifeskim |
| pubmed-article:1977810 | lifeskim:mentions | umls-concept:C0023206 | lld:lifeskim |
| pubmed-article:1977810 | lifeskim:mentions | umls-concept:C1709793 | lld:lifeskim |
| pubmed-article:1977810 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1977810 | pubmed:dateCreated | 1990-12-21 | lld:pubmed |
| pubmed-article:1977810 | pubmed:abstractText | In quantitative experiments using ELISA, binding of Tamm-Horsfall protein (THP) to uropathogenic Escherichia coli was studied with monoclonal antibody to THP. Adherence to E. coli bearing type 1 fimbriae was proportional to THP concentration and size of the bacterial inoculum. Type 1 fimbriae-bearing E. coli bound 50 times more THP than did non-type 1-fimbriated or P-fimbriated strains. Concanavalin A and wheat germ agglutinin bound THP in a dose-dependent fashion, whereas pokeweed mitogen and Vicia villosa B4 isolectin did not. Addition of mannose and N-acetylglucosamine reduced adherence of THP to concanavalin A and wheat germ agglutinin by 50%-80%. Sugar inhibition studies suggested that the fimbrial receptor site for THP has lectin-like properties and that THP binds to fimbriae via its mannose side chains. This quantitative assay is useful for studying the interaction between THP, uroepithelial cells, and bacteria in vitro. | lld:pubmed |
| pubmed-article:1977810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1977810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977810 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1977810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1977810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1977810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1977810 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1977810 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:1977810 | pubmed:author | pubmed-author:SobelJ DJD | lld:pubmed |
| pubmed-article:1977810 | pubmed:author | pubmed-author:ObedeanuNN | lld:pubmed |
| pubmed-article:1977810 | pubmed:author | pubmed-author:ReinhartH HHH | lld:pubmed |
| pubmed-article:1977810 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1977810 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:1977810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1977810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1977810 | pubmed:pagination | 1335-40 | lld:pubmed |
| pubmed-article:1977810 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:1977810 | pubmed:meshHeading | pubmed-meshheading:1977810-... | lld:pubmed |
| pubmed-article:1977810 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1977810 | pubmed:articleTitle | Quantitation of Tamm-Horsfall protein binding to uropathogenic Escherichia coli and lectins. | lld:pubmed |
| pubmed-article:1977810 | pubmed:affiliation | Department of Medicine, Wayne State University, Detroit, Michigan. | lld:pubmed |
| pubmed-article:1977810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1977810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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