| pubmed-article:1977656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C1337112 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C0017263 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C0796344 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:1977656 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:1977656 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1977656 | pubmed:dateCreated | 1990-12-5 | lld:pubmed |
| pubmed-article:1977656 | pubmed:abstractText | The Enhancer of zeste [E(z)] locus of Drosophila melanogaster is implicated in multiple examples of gene regulation during development. First identified as dominant gain-of-function modifiers of the zeste1-white (z-w) interaction, mutant E(z) alleles also produce homeotic transformations. Reduction of E(z)+ activity leads to both suppression of the z-w interaction and ectopic expression of segment identity genes of the Antennapedia and bithorax gene complexes. This latter effect defines E(z) as a member of the Polycomb-group of genes. Analysis of E(z)S2, a temperature-sensitive E(z) allele, reveals that both maternally and zygotically produced E(z)+ activity is required to correctly regulate the segment identity genes during embryonic and imaginal development. As has been shown for other Polycomb-group genes, E(z)+ is required not to initiate the pattern of these genes, but rather to maintain their repressed state. We propose that the E(z) loss-of-function eye color and homeotic phenotypes may both be due to gene derepression, and that the E(z)+ product may be a general repressing factor required for both examples of negative gene regulation. | lld:pubmed |
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| pubmed-article:1977656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1977656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977656 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1977656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1977656 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1977656 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:1977656 | pubmed:author | pubmed-author:JonesR SRS | lld:pubmed |
| pubmed-article:1977656 | pubmed:author | pubmed-author:GelbartW MWM | lld:pubmed |
| pubmed-article:1977656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1977656 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:1977656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1977656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1977656 | pubmed:pagination | 185-99 | lld:pubmed |
| pubmed-article:1977656 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
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| pubmed-article:1977656 | pubmed:meshHeading | pubmed-meshheading:1977656-... | lld:pubmed |
| pubmed-article:1977656 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1977656 | pubmed:articleTitle | Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. | lld:pubmed |
| pubmed-article:1977656 | pubmed:affiliation | Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138-2097. | lld:pubmed |
| pubmed-article:1977656 | pubmed:publicationType | Journal Article | lld:pubmed |
