| pubmed-article:1977323 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0178324 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0064830 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1977323 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:1977323 | pubmed:issue | 4 Pt 1 | lld:pubmed |
| pubmed-article:1977323 | pubmed:dateCreated | 1990-11-21 | lld:pubmed |
| pubmed-article:1977323 | pubmed:abstractText | We studied the effects of pretreatment of rabbits with a monoclonal antibody (MoAb) IB4 directed against an epitope on the common beta-chain of leukocyte adhesion glycoprotein CD18 on the development of pulmonary edema following pulmonary artery occlusion and reperfusion. A balloon catheter occluded the right pulmonary artery in rabbits for 24 h, and the balloon was then deflated to allow reperfusion for 2 h. The lungs were removed, attached to a weighing balance, and perfused with Ringer-albumin solution (0.5 g/100 ml). IB4 (0.5 mg/kg) was infused 45 min before the start of reperfusion. In another experiment, we infused OKM-1 (0.5 mg/kg), a control MoAb directed against an irrelevant epitope on the alpha-chain of CD11b/CD18. IB4 prevented rabbit neutrophil adherence to pulmonary artery endothelial cells in vitro in response to a variety of stimuli, whereas OKM-1 was ineffective. Pulmonary artery occlusion and reperfusion increased the lung myeloperoxidase (MPO) content, whereas IB4 prevented the increase in MPO content. The increase in lung weight in the IB4-treated group (400 +/- 40 mg from baseline) was less (P less than 0.001) than in the untreated control group (1,400 +/- 90 mg) and the OKM-1-treated control group (1,320 +/- 125 mg). IB4 pretreatment also prevented the increase in pulmonary capillary filtration coefficient (a measure of capillary permeability to water) occurring in control and OKM-1-treated groups. The results indicate that neutrophil sequestration in the pulmonary microcirculation mediated by CD18 glycoprotein is a major determinant of reperfusion-induced lung vascular injury. | lld:pubmed |
| pubmed-article:1977323 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1977323 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1977323 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977323 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1977323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1977323 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1977323 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1977323 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1977323 | pubmed:author | pubmed-author:MalikA BAB | lld:pubmed |
| pubmed-article:1977323 | pubmed:author | pubmed-author:WrightS DSD | lld:pubmed |
| pubmed-article:1977323 | pubmed:author | pubmed-author:HorganM JMJ | lld:pubmed |
| pubmed-article:1977323 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1977323 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:1977323 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1977323 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1977323 | pubmed:pagination | L315-9 | lld:pubmed |
| pubmed-article:1977323 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1977323 | pubmed:meshHeading | pubmed-meshheading:1977323-... | lld:pubmed |
| pubmed-article:1977323 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1977323 | pubmed:articleTitle | Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury. | lld:pubmed |
| pubmed-article:1977323 | pubmed:affiliation | Department of Pediatrics, Albany Medical College of Union University, New York 12208. | lld:pubmed |
| pubmed-article:1977323 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1977323 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1977323 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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