| pubmed-article:1976883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1976883 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:1976883 | lifeskim:mentions | umls-concept:C0239307 | lld:lifeskim |
| pubmed-article:1976883 | lifeskim:mentions | umls-concept:C0085110 | lld:lifeskim |
| pubmed-article:1976883 | lifeskim:mentions | umls-concept:C0596545 | lld:lifeskim |
| pubmed-article:1976883 | pubmed:issue | 8719 | lld:pubmed |
| pubmed-article:1976883 | pubmed:dateCreated | 1990-11-21 | lld:pubmed |
| pubmed-article:1976883 | pubmed:abstractText | The outcome of bone-marrow transplantations (BMT) carried out between 1968 and March 1, 1989, in 183 patients with severe combined immunodeficiency (SCID) was analysed. Recipients of HLA-identical BMTs (70) had a 76% probability of survival (median follow-up 73 months). Of the 32 treated since 1983, 97% have been cured (median follow-up 41 months). This good prognosis was associated with rapid development of T and B cell function. HLA-non-identical, T-cell-depleted, BMT (n = 100) gave significantly lower survival (52%; median follow-up 47 months). Factors associated with poor prognosis were the presence of a lung infection before BMT, absence of a protected environment, and use of female donors for male recipients. Use of a conditioning regimen significantly increased the frequency of sustained engraftment (86% vs 50% for non-conditioned BMT) and resulted in more frequent engraftment of donor B lymphocytes and myeloid cells. Donor B-cell chimerism was strongly associated with the development of normal B-cell function. | lld:pubmed |
| pubmed-article:1976883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1976883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1976883 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1976883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1976883 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1976883 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:GriscelliCC | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:FischerAA | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:MorganGG | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:FasthAA | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:FriedrichWW | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:PortaFF | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:LandaisPP | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:LevinskyRR | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:GerritsenBB | lld:pubmed |
| pubmed-article:1976883 | pubmed:author | pubmed-author:GoldmanS FSF | lld:pubmed |
| pubmed-article:1976883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1976883 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:1976883 | pubmed:volume | 336 | lld:pubmed |
| pubmed-article:1976883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1976883 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1976883 | pubmed:pagination | 850-4 | lld:pubmed |
| pubmed-article:1976883 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1976883 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1976883 | pubmed:articleTitle | European experience of bone-marrow transplantation for severe combined immunodeficiency. | lld:pubmed |
| pubmed-article:1976883 | pubmed:affiliation | Immunology and Haematology Unit, Hôpital Necker-Enfants Malades, Paris, France. | lld:pubmed |
| pubmed-article:1976883 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1976883 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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