| pubmed-article:1976824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C0282632 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1976824 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1976824 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1976824 | pubmed:dateCreated | 1990-11-15 | lld:pubmed |
| pubmed-article:1976824 | pubmed:abstractText | Evidence of antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection via Fc receptor (FcR) was published previously (A. Takeda, C. U. Tuazon, and F. A. Ennis, Science 242:580-583, 1988). To define the entry mechanism of HIV-1 complexed with anti-HIV-1 antibody, we attempted to determine the receptor molecules responsible for mediating enhancement of HIV-1 infection of monocytic cells. Monoclonal antibodies to FcRI for immunoglobulin G substantially blocked antibody-dependent enhancement of HIV-1 infection. Furthermore, we demonstrate a requirement for the CD4 molecule in antibody-enhanced HIV-1 infection via FcR. Soluble CD4 prevented infection by HIV-1 antibody-treated virus, and enhancement of infection of virus-antibody complexes was abrogated by a monoclonal antibody to CD4 (anti-Leu3a antibody). Treatment of human macrophages with an anti-CD4 antibody also inhibited antibody-enhanced HIV-1 infection of macrophages, supporting our contention that antibody-dependent enhancement of HIV-1 infection via FcR requires CD4 interaction with the virus glycoprotein. | lld:pubmed |
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| pubmed-article:1976824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1976824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1976824 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1976824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1976824 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1976824 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1976824 | pubmed:author | pubmed-author:TakedaAA | lld:pubmed |
| pubmed-article:1976824 | pubmed:author | pubmed-author:SweetR WRW | lld:pubmed |
| pubmed-article:1976824 | pubmed:author | pubmed-author:EnnisF AFA | lld:pubmed |
| pubmed-article:1976824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1976824 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:1976824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1976824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1976824 | pubmed:pagination | 5605-10 | lld:pubmed |
| pubmed-article:1976824 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1976824 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1976824 | pubmed:articleTitle | Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R. | lld:pubmed |
| pubmed-article:1976824 | pubmed:affiliation | Department of Medicine, University of Massachusetts Medical School, Worcester 01655. | lld:pubmed |
| pubmed-article:1976824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1976824 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1976824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1976824 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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