| pubmed-article:1976734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0014372 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1976734 | lifeskim:mentions | umls-concept:C0221117 | lld:lifeskim |
| pubmed-article:1976734 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1976734 | pubmed:dateCreated | 1990-11-1 | lld:pubmed |
| pubmed-article:1976734 | pubmed:abstractText | The cellular basis of the in vitro and in vivo T cell responses to Staphylococcus enterotoxin B (SEB) has been investigated. The proliferation and cytotoxicity of V beta 8.1,2+,CD4+ and CD8+ T cells were observed in in vitro response to SEB. In primary cytotoxicity assays, CD4+ T cells from control spleens were more active than their CD8+ counterparts, however, in cells derived from SEB-primed mice, CD8+ T cells were dominant in SEB-specific cytotoxicity. In vivo priming with SEB abrogated the response of V beta 8.1,2+,CD4+ T cells despite the fact that these cells exist in significant number. This SEB-specific anergy occurred only in V beta 8.1,2+,CD4+ T cells but not in CD8+ T cells. These findings indicate that the requirement for the induction of antigen-specific anergy is different between CD4+ and CD8+ T cells in post-thymic tolerance, and the existence of coanergic signals for the induction of T cell anergy is suggested. | lld:pubmed |
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| pubmed-article:1976734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1976734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1976734 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1976734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1976734 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1976734 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1976734 | pubmed:author | pubmed-author:KawabeYY | lld:pubmed |
| pubmed-article:1976734 | pubmed:author | pubmed-author:OchiAA | lld:pubmed |
| pubmed-article:1976734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1976734 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1976734 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:1976734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1976734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1976734 | pubmed:pagination | 1065-70 | lld:pubmed |
| pubmed-article:1976734 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1976734 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1976734 | pubmed:articleTitle | Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice. | lld:pubmed |
| pubmed-article:1976734 | pubmed:affiliation | Department of Immunology and Medical Genetics, University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:1976734 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1976734 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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