| pubmed-article:19762714 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C0287531 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C1705047 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C0029431 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:19762714 | lifeskim:mentions | umls-concept:C1333257 | lld:lifeskim |
| pubmed-article:19762714 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19762714 | pubmed:dateCreated | 2009-10-7 | lld:pubmed |
| pubmed-article:19762714 | pubmed:abstractText | Bone mass is maintained through the complementary activities of osteoblasts and osteoclasts; yet differentiation of either osteoblasts and osteoclasts engages the mitogen-activated protein kinase (MAPK) pathway. The MAPKs are negatively regulated by a family of dual-specificity phosphatases known as the MAPK phosphatases (MKPs). MKP-1 is a stress-responsive MKP that inactivates the MAPKs and plays a central role in macrophages; however, whether MKP-1 plays a role in the maintenance of bone mass has yet to be investigated. We show here, using a genetic approach, that mkp-1(-/-) female mice exhibited slightly reduced bone mass. We found that mkp-1(+/+) and mkp-1(-/-) mice had equivalent levels of bone loss after ovariectomy despite mkp-1(-/-) mice having fewer osteoclasts, suggesting that mkp-1(-/-) osteoclasts are hyperactive. Indeed, deletion of MKP1 led to a profound activation of osteoclasts in vivo in response to local lipopolysaccharide (LPS) injection. These results suggest a role for MKP-1 in osteoclasts, which originate from the fusion of macrophages. In support of these observations, receptor activator for nuclear factor-kappaB ligand induced the expression for MKP-1, and osteoclasts derived from mkp-1(-/-) mice had increased resorptive activity. Finally, receptor activator of nuclear factor-kappaB ligand-induced p38 MAPK and c-Jun NH2-terminal kinase activities were enhanced in osteoclasts derived from mkp-1(-/-) mice. Taken together, these results show that MKP-1 plays a role in the maintenance of bone mass and does so by negatively regulating MAPK-dependent osteoclast signaling. | lld:pubmed |
| pubmed-article:19762714 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19762714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19762714 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19762714 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19762714 | pubmed:issn | 1525-2191 | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:ZhangQingQ | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:BennettAnton... | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:XuXiaoqingX | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:CuiWeiguoW | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:VigneryAgnèsA | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:CarlsonJodiJ | lld:pubmed |
| pubmed-article:19762714 | pubmed:author | pubmed-author:MercanFatihF | lld:pubmed |
| pubmed-article:19762714 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19762714 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:19762714 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19762714 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19762714 | pubmed:pagination | 1564-73 | lld:pubmed |
| pubmed-article:19762714 | pubmed:dateRevised | 2010-10-4 | lld:pubmed |
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| pubmed-article:19762714 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19762714 | pubmed:articleTitle | Role of MKP-1 in osteoclasts and bone homeostasis. | lld:pubmed |
| pubmed-article:19762714 | pubmed:affiliation | Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:19762714 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19762714 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:19252 | entrezgene:pubmed | pubmed-article:19762714 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19762714 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19762714 | lld:pubmed |
