| pubmed-article:19760183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0598782 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0080347 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C1426082 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0683705 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C1260950 | lld:lifeskim |
| pubmed-article:19760183 | lifeskim:mentions | umls-concept:C0998631 | lld:lifeskim |
| pubmed-article:19760183 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19760183 | pubmed:dateCreated | 2010-1-21 | lld:pubmed |
| pubmed-article:19760183 | pubmed:abstractText | The genes encoding the closely related zinc finger transcription factors Buttonhead (Btd) and D-Sp1 are expressed in the developing limb primordia of Drosophila melanogaster and are required for normal growth of the legs. The D-Sp1 homolog of the red flour beetle Tribolium castaneum, Sp8 (appropriately termed Sp8/9), is also required for the proper growth of the leg segments. Here we report on the isolation and functional study of the Sp8/9 gene from the milkweed bug Oncopeltus fasciatus. We show that Sp8/9 is expressed in the developing appendages throughout development and that the downregulation of Sp8/9 via RNAi leads to antennae, rostrum, and legs with shortened and fused segments. This supports a conserved role of Sp8/9 in allometric leg segment growth. However, all leg segments including the claws are present and the expression of the leg genes Distal-less, dachshund, and homothorax are proportionally normal, thus providing no evidence for a role of Sp8/9 in appendage specification. | lld:pubmed |
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| pubmed-article:19760183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19760183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19760183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19760183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19760183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19760183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19760183 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19760183 | pubmed:issn | 1432-041X | lld:pubmed |
| pubmed-article:19760183 | pubmed:author | pubmed-author:WimmerErnst... | lld:pubmed |
| pubmed-article:19760183 | pubmed:author | pubmed-author:PrpicNikola-M... | lld:pubmed |
| pubmed-article:19760183 | pubmed:author | pubmed-author:SchaeperNina... | lld:pubmed |
| pubmed-article:19760183 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19760183 | pubmed:volume | 219 | lld:pubmed |
| pubmed-article:19760183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19760183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19760183 | pubmed:pagination | 427-35 | lld:pubmed |
| pubmed-article:19760183 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:meshHeading | pubmed-meshheading:19760183... | lld:pubmed |
| pubmed-article:19760183 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19760183 | pubmed:articleTitle | A conserved function of the zinc finger transcription factor Sp8/9 in allometric appendage growth in the milkweed bug Oncopeltus fasciatus. | lld:pubmed |
| pubmed-article:19760183 | pubmed:affiliation | Georg-August-Universität, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Abteilung Entwicklungsbiologie, GZMB, Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, Göttingen, Germany. | lld:pubmed |
| pubmed-article:19760183 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19760183 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19760183 | lld:pubmed |
