| pubmed-article:19756605 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C0005508 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19756605 | lifeskim:mentions | umls-concept:C1999678 | lld:lifeskim |
| pubmed-article:19756605 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19756605 | pubmed:dateCreated | 2010-3-16 | lld:pubmed |
| pubmed-article:19756605 | pubmed:abstractText | SR13668 (2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole), is a new candidate cancer chemopreventive agent under development. It was designed using computational modeling based on a naturally occurring indole-3-carbinol and its in vivo condensation products. It showed promising anti-cancer activity and its preclinical toxicology profile (genotoxicity battery and subchronic rat and dog studies) was unremarkable. However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability. | lld:pubmed |
| pubmed-article:19756605 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19756605 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19756605 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19756605 | pubmed:month | May | lld:pubmed |
| pubmed-article:19756605 | pubmed:issn | 1432-0843 | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:CrowellJames... | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:HuShu-ChiehSC | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:RajewskiRoger... | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:KapetanovicIz... | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:McCormickDavi... | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:JongLingL | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:HaslamJohn... | lld:pubmed |
| pubmed-article:19756605 | pubmed:author | pubmed-author:MuzzioMiguelM | lld:pubmed |
| pubmed-article:19756605 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19756605 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:19756605 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19756605 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19756605 | pubmed:pagination | 1109-16 | lld:pubmed |
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| pubmed-article:19756605 | pubmed:meshHeading | pubmed-meshheading:19756605... | lld:pubmed |
| pubmed-article:19756605 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19756605 | pubmed:articleTitle | Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. | lld:pubmed |
| pubmed-article:19756605 | pubmed:affiliation | Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., Rm. 2116, Bethesda, MD 20892, USA. kapetani@mail.nih.gov | lld:pubmed |
| pubmed-article:19756605 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19756605 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19756605 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19756605 | lld:pubmed |
