| pubmed-article:19754954 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C0026559 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19754954 | lifeskim:mentions | umls-concept:C1880287 | lld:lifeskim |
| pubmed-article:19754954 | pubmed:dateCreated | 2009-9-30 | lld:pubmed |
| pubmed-article:19754954 | pubmed:abstractText | The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in approximately 30% of human breast cancers. Phosphorylation of the translation initiation factor, eIF2alpha inhibits global protein synthesis and activates a stress signaling and growth suppressive program. We have shown that forced phosphorylation of eIF2alpha can suppress head and neck, colorectal carcinoma and multiple myeloma tumor growth and/or survival. Here we explore whether ErbB2 modulates eIF2alpha phosphorylation and whether forced phosphorylation of the latter can antagonize ErbB2 deregulation of mammary acinar morphogenesis. | lld:pubmed |
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| pubmed-article:19754954 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19754954 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19754954 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19754954 | pubmed:issn | 1471-2121 | lld:pubmed |
| pubmed-article:19754954 | pubmed:author | pubmed-author:FariasEduardo... | lld:pubmed |
| pubmed-article:19754954 | pubmed:author | pubmed-author:Aguirre-Ghiso... | lld:pubmed |
| pubmed-article:19754954 | pubmed:author | pubmed-author:SequeiraSharo... | lld:pubmed |
| pubmed-article:19754954 | pubmed:author | pubmed-author:WenHuei ChiHC | lld:pubmed |
| pubmed-article:19754954 | pubmed:author | pubmed-author:Avivar-Valder... | lld:pubmed |
| pubmed-article:19754954 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19754954 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19754954 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19754954 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19754954 | pubmed:pagination | 64 | lld:pubmed |
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| pubmed-article:19754954 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19754954 | pubmed:articleTitle | Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. | lld:pubmed |
| pubmed-article:19754954 | pubmed:affiliation | Department of Medicine, Division of Hematology and Oncology, Tisch Cancer Institute at Mount Sinai, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. ss7267@albany.edu | lld:pubmed |
| pubmed-article:19754954 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19754954 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19754954 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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