| pubmed-article:19747858 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0008300 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C2347644 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19747858 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19747858 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19747858 | pubmed:dateCreated | 2009-9-21 | lld:pubmed |
| pubmed-article:19747858 | pubmed:abstractText | The lineage fate of developing thymocytes is determined by the persistence or cessation of T cell receptor (TCR) signaling during positive selection, with persistent TCR signaling required for CD4 lineage choice. We show here that transcriptional upregulation of CD4 expression is essential for error-free lineage choice during major histocompatibility complex class II (MHC II)-specific positive selection and is critical for error-free lineage choice in TCR-transgenic mice whose thymocytes compete for the identical selecting ligand. CD4 upregulation occurred for endogenously encoded CD4 coreceptors, but CD4 transgenes were downregulated during positive selection, disrupting MHC II-specific TCR signaling and causing lineage errors regardless of the absolute number or signaling strength of transgenic CD4 proteins. Thus, the kinetics of CD4 coreceptor expression during MHC II-specific positive selection determines the integrity of CD4 lineage choice, revealing an elegant symmetry between coreceptor kinetics and lineage choice. | lld:pubmed |
| pubmed-article:19747858 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19747858 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19747858 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19747858 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19747858 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:ErwayBB | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:SingerAlfredA | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:SharrowSusan... | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:FeigenbaumLio... | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:SarafovaSophi... | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:GuinterTerryT | lld:pubmed |
| pubmed-article:19747858 | pubmed:author | pubmed-author:AdoroStanleyS | lld:pubmed |
| pubmed-article:19747858 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19747858 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:19747858 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19747858 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19747858 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19747858 | pubmed:pagination | 480-90 | lld:pubmed |
| pubmed-article:19747858 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:meshHeading | pubmed-meshheading:19747858... | lld:pubmed |
| pubmed-article:19747858 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19747858 | pubmed:articleTitle | Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. | lld:pubmed |
| pubmed-article:19747858 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:19747858 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19747858 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| entrez-gene:12010 | entrezgene:pubmed | pubmed-article:19747858 | lld:entrezgene |
| entrez-gene:12504 | entrezgene:pubmed | pubmed-article:19747858 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19747858 | lld:entrezgene |
