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| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C1167149 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C0080347 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C0001998 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C1421713 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C1826700 | lld:lifeskim |
| pubmed-article:19741270 | lifeskim:mentions | umls-concept:C0052336 | lld:lifeskim |
| pubmed-article:19741270 | pubmed:issue | 47 | lld:pubmed |
| pubmed-article:19741270 | pubmed:dateCreated | 2009-11-16 | lld:pubmed |
| pubmed-article:19741270 | pubmed:abstractText | Gene transcription in eukaryotes is modulated by the coordinated recruitment of specific transcription factors and chromatin-modulating proteins. Indeed, gene activation and/or repression is/are regulated by histone methylation status at specific arginine or lysine residues. In this work, by co-immunoprecipitation experiments, we demonstrate that PRMT5, a type II protein arginine methyltransferase that monomethylates and symmetrically dimethylates arginine residues, is physically associated with the Kruppel-like associated box-zinc finger protein ZNF224, the aldolase A gene repressor. Moreover, chromatin immunoprecipitation assays show that PRMT5 is recruited to the L-type aldolase A promoter and that methylation of the nucleosomes that surround the L-type promoter region occurs in vivo on the arginine 3 of histone H4. Consistent with its association to the ZNF224 repressor complex, the decrease of PRMT5 expression produced by RNA interference positively affects L-type aldolase A promoter transcription. Finally, the alternating occupancy of the L-type aldolase A promoter by the ZNF224-PRMT5 repression complex in proliferating and growth-arrested cells suggests that these regulatory proteins play a significant role during the cell cycle modulation of human aldolase A gene expression. Our data represent the first experimental evidence that protein arginine methylation plays a role in ZNF224-mediated transcriptional repression and provide novel insight into the chromatin modifications required for repression of gene transcription by Kruppel-like associated box-zinc finger proteins. | lld:pubmed |
| pubmed-article:19741270 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19741270 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19741270 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19741270 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19741270 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19741270 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:IzzoPaolaP | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:GrossoMichela... | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:CostanzoPaola... | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:MedugnoLinaL | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:FlorioFrances... | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:LupoAngeloA | lld:pubmed |
| pubmed-article:19741270 | pubmed:author | pubmed-author:CesaroElenaE | lld:pubmed |
| pubmed-article:19741270 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19741270 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:19741270 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:19741270 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19741270 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19741270 | pubmed:pagination | 32321-30 | lld:pubmed |
| pubmed-article:19741270 | pubmed:dateRevised | 2011-3-3 | lld:pubmed |
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| pubmed-article:19741270 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19741270 | pubmed:articleTitle | The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene. | lld:pubmed |
| pubmed-article:19741270 | pubmed:affiliation | Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Via S. Pansini 5, Napoli 80131, Italy. | lld:pubmed |
| pubmed-article:19741270 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19741270 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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