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pubmed-article:19740411pubmed:abstractTextFibroblast Growth Factors (FGF) and their receptors are well known for having major implications in cell signalling controlling embryonic development. Recently, a gene coding for a protein closely related to FGFRs (Fibroblast Growth Factor Receptors) called FGFR5 or FGFR-like 1 (FGFRL1), has been described in vertebrates. An orthologous gene was also found in the cephalochordate amphioxus, but no orthologous genes were found by the authors in other non-vertebrate species, even if a FGFRL1 gene was identified in the sea urchin genome, as well as a closely related gene, named nou-darake, in the planarian Dugesia japonica. These intriguing data of a deuterostome-specific gene that might be implicated in FGF signalling prompted us to search for putative FGFRL1 orthologues in the completely sequenced genomes of metazoans.lld:pubmed
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pubmed-article:19740411pubmed:authorpubmed-author:LamonerieThom...lld:pubmed
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pubmed-article:19740411pubmed:articleTitleFGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla.lld:pubmed
pubmed-article:19740411pubmed:affiliationDepartament de Genètica, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, edifici annex, 1a planta, 08028 Barcelona, España. stephanie.bertrand@obs-banyuls.frlld:pubmed
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