| pubmed-article:19739223 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19739223 | lifeskim:mentions | umls-concept:C0028606 | lld:lifeskim |
| pubmed-article:19739223 | lifeskim:mentions | umls-concept:C0600436 | lld:lifeskim |
| pubmed-article:19739223 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19739223 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19739223 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:19739223 | pubmed:issue | 39 | lld:pubmed |
| pubmed-article:19739223 | pubmed:dateCreated | 2009-10-5 | lld:pubmed |
| pubmed-article:19739223 | pubmed:abstractText | Oligonucleotides composed of 1',5'-anhydro-arabino-hexitol nucleosides belonging to the L series (L-HNA) were prepared and preliminarily studied as a novel potential base-pairing system. Synthesis of enantiopure L-hexitol nucleotide monomers equipped with a 2'-(N(6)-benzoyladenin-9-yl) or a 2'-(thymin-1-yl) moiety was carried out by a de novo approach based on a domino reaction as key step. The L oligonucleotide analogues were evaluated in duplex formation with natural complements as well as with unnatural sugar-modified oligonucleotides. In many cases stable homo- and heterochiral associations were found. Besides T(m) measurements, detection of heterochiral complexes was unambiguously confirmed by LC-MS studies. Interestingly, circular dichroism measurements of the most stable duplexes suggested that L-HNA form left-handed helices with both D and L oligonucleotides. | lld:pubmed |
| pubmed-article:19739223 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19739223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19739223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19739223 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19739223 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19739223 | pubmed:issn | 1521-3765 | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:RozenskiJefJ | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:HerdewijnPiet... | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:SchepersGuyG | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:GuaragnaAnnal... | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:PalumboGiovan... | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:CaponeStefani... | lld:pubmed |
| pubmed-article:19739223 | pubmed:author | pubmed-author:D'AlonzoDanie... | lld:pubmed |
| pubmed-article:19739223 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19739223 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:19739223 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19739223 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19739223 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19739223 | pubmed:pagination | 10121-31 | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:meshHeading | pubmed-meshheading:19739223... | lld:pubmed |
| pubmed-article:19739223 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19739223 | pubmed:articleTitle | Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA). | lld:pubmed |
| pubmed-article:19739223 | pubmed:affiliation | Dipartimento di Chimica Organica e Biochimica, Università Federico II, Napoli, via Cinthia 4, 80126 Napoli, Italy. | lld:pubmed |
| pubmed-article:19739223 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19739223 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
