| pubmed-article:19720997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C0030012 | lld:lifeskim |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C1366764 | lld:lifeskim |
| pubmed-article:19720997 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19720997 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:19720997 | pubmed:dateCreated | 2009-10-6 | lld:pubmed |
| pubmed-article:19720997 | pubmed:abstractText | Base excision repair (BER) enzymes maintain the integrity of the genome, and in humans, BER mutations are associated with cancer. Given the remarkable sensitivity of DNA-mediated charge transport (CT) to mismatched and damaged base pairs, we have proposed that DNA repair glycosylases (EndoIII and MutY) containing a redox-active [4Fe4S] cluster could use DNA CT in signaling one another to search cooperatively for damage in the genome. Here, we examine this model, where we estimate that electron transfers over a few hundred base pairs are sufficient for rapid interrogation of the full genome. Using atomic force microscopy, we found a redistribution of repair proteins onto DNA strands containing a single base mismatch, consistent with our model for CT scanning. We also demonstrated in Escherichia coli a cooperativity between EndoIII and MutY that is predicted by the CT scanning model. This relationship does not require the enzymatic activity of the glycosylase. Y82A EndoIII, a mutation that renders the protein deficient in DNA-mediated CT, however, inhibits cooperativity between MutY and EndoIII. These results illustrate how repair proteins might efficiently locate DNA lesions and point to a biological role for DNA-mediated CT within the cell. | lld:pubmed |
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| pubmed-article:19720997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19720997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19720997 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19720997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19720997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19720997 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19720997 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:BartonJacquel... | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:NewmanDianne... | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:GralnickJeffr... | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:BoalAmie KAK | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:GenereuxJosep... | lld:pubmed |
| pubmed-article:19720997 | pubmed:author | pubmed-author:SontzPamela... | lld:pubmed |
| pubmed-article:19720997 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19720997 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:19720997 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19720997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19720997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19720997 | pubmed:pagination | 15237-42 | lld:pubmed |
| pubmed-article:19720997 | pubmed:dateRevised | 2010-9-29 | lld:pubmed |
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| pubmed-article:19720997 | pubmed:meshHeading | pubmed-meshheading:19720997... | lld:pubmed |
| pubmed-article:19720997 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19720997 | pubmed:articleTitle | Redox signaling between DNA repair proteins for efficient lesion detection. | lld:pubmed |
| pubmed-article:19720997 | pubmed:affiliation | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. | lld:pubmed |
| pubmed-article:19720997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19720997 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19720997 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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