| pubmed-article:1971811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C0013036 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1971811 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1971811 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:1971811 | pubmed:dateCreated | 1990-7-6 | lld:pubmed |
| pubmed-article:1971811 | pubmed:abstractText | Activation of renal dopamine-1 receptors decreases sodium transport. However, the spontaneously hypertensive rat retains sodium despite increased renal dopamine concentration. We tested the hypothesis that the abnormal sodium handling in spontaneously hypertensive rats (Okamoto-Aoki strain) is related to a decreased dopaminergic response by studying the effects of the intrarenal infusion of the dopamine-1 agonist SKF-38393 and the dopamine-1 antagonist SCH-23390 in hypertensive and in normotensive Wistar-Kyoto rats. Rats (9-16 weeks old) were studied with renal nerves intact under pentobarbital anesthesia (n = 5-6 in each group). Specificity of dopamine-1 effects of SKF-38393 was verified because its natriuretic effect was blocked in a dose-related manner by the dopamine-1 antagonist SCH-23390 (n = 5). Intrarenal but resulted in a dose-related natriuresis and diuresis in normotensive but not in hypertensive rats. Intrarenal arterial infusion of the dopamine-1 antagonist SCH-23390 alone induced an antinatriuresis, without affecting glomerular filtration rate, in normotensive but not in hypertensive rats. Addition of the dopamine-2 antagonist YM-09151 to the dopamine-1 antagonist infusion did not enhance the effect of the dopamine-1 antagonist. The lack of response to the dopamine-1 agonist or antagonist in hypertensive rats was not due to differences in renal dopamine-1 receptor density (1.3 +/- 0.3 pmol/mg protein for spontaneously hypertensive rats, n = 4; 1 +/- 0.2 for Wistar-Kyoto rats, n = 4) or affinity; distribution determined by autoradiography was also similar. The abnormal renal sodium handling in 9-16-week-old spontaneously hypertensive rats is in part due to decreased response distal to the dopamine-1 receptor. | lld:pubmed |
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| pubmed-article:1971811 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1971811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1971811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1971811 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1971811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1971811 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1971811 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1971811 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:1971811 | pubmed:author | pubmed-author:EisnerG MGM | lld:pubmed |
| pubmed-article:1971811 | pubmed:author | pubmed-author:JoseP APA | lld:pubmed |
| pubmed-article:1971811 | pubmed:author | pubmed-author:CoenDD | lld:pubmed |
| pubmed-article:1971811 | pubmed:author | pubmed-author:FelderR ARA | lld:pubmed |
| pubmed-article:1971811 | pubmed:author | pubmed-author:SeikalyM GMG | lld:pubmed |
| pubmed-article:1971811 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1971811 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:1971811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1971811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1971811 | pubmed:pagination | 560-9 | lld:pubmed |
| pubmed-article:1971811 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1971811 | pubmed:meshHeading | pubmed-meshheading:1971811-... | lld:pubmed |
| pubmed-article:1971811 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1971811 | pubmed:articleTitle | Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. | lld:pubmed |
| pubmed-article:1971811 | pubmed:affiliation | Department of Pathology, University of Virginia Medical Center, Charlottesville. | lld:pubmed |
| pubmed-article:1971811 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1971811 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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