| pubmed-article:19717648 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:19717648 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:19717648 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:19717648 | pubmed:dateCreated | 2009-10-30 | lld:pubmed |
| pubmed-article:19717648 | pubmed:abstractText | CCAAT/enhancer-binding protein beta (C/EBPbeta), also known as nuclear factor-interleukin-6 (NF-IL6), is a transcription factor that plays an important role in the regulation of growth and differentiation of myeloid and lymphoid cells. Mice deficient in C/EBPbeta show impaired generation of B lymphocytes. We show that C/EBPbeta regulates transcription factors critical for proliferation and survival in multiple myeloma. Multiple myeloma cell lines and primary multiple myeloma cells strongly expressed C/EBPbeta, whereas normal B cells and plasma cells had little or no detectable levels of C/EBPbeta. Silencing of C/EBPbeta led to down-regulation of transcription factors such as IRF4, XBP1, and BLIMP1 accompanied by a strong inhibition of proliferation. Further, silencing of C/EBPbeta led to a complete down-regulation of antiapoptotic B-cell lymphoma 2 (BCL2) expression. In chromatin immunoprecipitation assays, C/EBPbeta directly bound to the promoter region of IRF4, BLIMP1, and BCL2. Our data indicate that C/EBPbeta is involved in the regulatory network of transcription factors that are critical for plasma cell differentiation and survival. Targeting C/EBPbeta may provide a novel therapeutic strategy in the treatment of multiple myeloma. | lld:pubmed |
| pubmed-article:19717648 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19717648 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19717648 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19717648 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19717648 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19717648 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19717648 | pubmed:author | pubmed-author:RoodmanG... | lld:pubmed |
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| pubmed-article:19717648 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19717648 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:19717648 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19717648 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19717648 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19717648 | pubmed:pagination | 3890-8 | lld:pubmed |
| pubmed-article:19717648 | pubmed:dateRevised | 2010-11-1 | lld:pubmed |
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| pubmed-article:19717648 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19717648 | pubmed:articleTitle | C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells. | lld:pubmed |
| pubmed-article:19717648 | pubmed:affiliation | Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. | lld:pubmed |
| pubmed-article:19717648 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19717648 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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