| pubmed-article:19716892 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19716892 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:19716892 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19716892 | lifeskim:mentions | umls-concept:C1424222 | lld:lifeskim |
| pubmed-article:19716892 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:19716892 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19716892 | pubmed:dateCreated | 2009-10-12 | lld:pubmed |
| pubmed-article:19716892 | pubmed:abstractText | Mutations in the DJ-1 gene have been linked with rare cases of early onset, autosomal recessive Parkinson's disease (PD). To determine whether DJ-1 is also involved in the pathogenesis of common forms of PD we have compared DJ-1 mRNA levels in a number of post-mortem PD and control brain regions using quantitative real-time PCR. Region-specific decreases were observed in DJ-1 mRNA levels in putamen, frontal cortex, parietal cortex and cerebellum in PD ( approximately 30-60%) compared to controls whilst an up-regulation was observed in the amygdala ( approximately 90%) and entorhinal cortex ( approximately 39%). Using quantitative western blot analysis, parallel decreases in DJ-1 protein levels were seen in frontal cortex, putamen and cerebellum of PD cases. By using 2-dimensional gel electrophoresis, we show preponderance of acidic pI isoforms of DJ-1 monomer in PD vulnerable regions, namely frontal cortex and medulla suggestive of differential post-translational modifications. Our findings point to a putative role of DJ-1 in the pathogenesis of PD. | lld:pubmed |
| pubmed-article:19716892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19716892 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19716892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19716892 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19716892 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19716892 | pubmed:issn | 1095-953X | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:WoodNicholas... | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:LeesAndrew... | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:HardyJohn AJA | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:RentonAlanA | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:BandopadhyayR... | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:SharmaSimoneS | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:LukConnieC | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:VandrovcovaJa... | lld:pubmed |
| pubmed-article:19716892 | pubmed:author | pubmed-author:KumaranRavind... | lld:pubmed |
| pubmed-article:19716892 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19716892 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:19716892 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19716892 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19716892 | pubmed:pagination | 393-400 | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
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| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:meshHeading | pubmed-meshheading:19716892... | lld:pubmed |
| pubmed-article:19716892 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19716892 | pubmed:articleTitle | Differential DJ-1 gene expression in Parkinson's disease. | lld:pubmed |
| pubmed-article:19716892 | pubmed:affiliation | Reta Lila Weston Institute of Neurological Disease, Institute of Neurology, University College London, 1, Wakefield Street, WC1N 1PJ, UK. | lld:pubmed |
| pubmed-article:19716892 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19716892 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19716892 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11315 | entrezgene:pubmed | pubmed-article:19716892 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19716892 | lld:entrezgene |
