| pubmed-article:1971509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0949771 | lld:lifeskim |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0597895 | lld:lifeskim |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
| pubmed-article:1971509 | lifeskim:mentions | umls-concept:C0596969 | lld:lifeskim |
| pubmed-article:1971509 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1971509 | pubmed:dateCreated | 1990-6-28 | lld:pubmed |
| pubmed-article:1971509 | pubmed:abstractText | Renal brush-border membrane vesicles from rat kidney cortex were irradiated in frozen state with a gamma-radiation source. Initial rates of influx into these vesicles were estimated for substrates such as L-glutamic acid, L-alanine, L-proline and L-leucine to establish the molecular sizes of their carriers. Transport was measured in initial-rate conditions to avoid artifacts arising from a decrease in the driving force caused by a modification of membrane permeability. Initial rates of Na(+)-independent uptakes for those four substrates appeared unaffected in the dose range used (0-6 Mrad), indicating that the passive permeability of the membrane towards these substrates was unaffected. However, at higher doses of irradiation the Na+ influx and the intravesicular volume evaluated by the uptake of glucose at equilibrium were altered by radiation. Thus Na(+)-dependent influx values were corrected for volume changes, and the corrected values were used to compute radiation-inactivation sizes of the transport systems. Their respective values for L-glutamic acid, L-proline, L-leucine and L-alanine carriers were 250, 224, 293 and 274 kDa. The presence of the free-radicals scavenger benzoic acid in the frozen samples during irradiation did not affect the uptake of glucose, phosphate and alkaline phosphatase activity. These results indicate that freezing samples in a cryoprotective medium was enough to prevent secondary inactivation of transporters by free radicals. Uptakes of beta-alanine and L-lysine were much less affected by radiation. The radiation-inactivation size of the Na(+)-dependent beta-alanine carrier was 127 kDa and that of the L-lysine carrier was 90 kDa. | lld:pubmed |
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| pubmed-article:1971509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1971509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1971509 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1971509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1971509 | pubmed:month | May | lld:pubmed |
| pubmed-article:1971509 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1971509 | pubmed:author | pubmed-author:PotierMM | lld:pubmed |
| pubmed-article:1971509 | pubmed:author | pubmed-author:JettéMM | lld:pubmed |
| pubmed-article:1971509 | pubmed:author | pubmed-author:BéliveauRR | lld:pubmed |
| pubmed-article:1971509 | pubmed:author | pubmed-author:DemeuleMM | lld:pubmed |
| pubmed-article:1971509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1971509 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1971509 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:1971509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1971509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1971509 | pubmed:pagination | 195-200 | lld:pubmed |
| pubmed-article:1971509 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1971509 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1971509 | pubmed:articleTitle | Molecular sizes of amino acid transporters in the luminal membrane from the kidney cortex, estimated by the radiation-inactivation method. | lld:pubmed |
| pubmed-article:1971509 | pubmed:affiliation | Département de Chimie, Université du Québec à Montréal, Quebec, Canada. | lld:pubmed |
| pubmed-article:1971509 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1971509 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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