| pubmed-article:1971256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1971256 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:1971256 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1971256 | pubmed:dateCreated | 1990-6-25 | lld:pubmed |
| pubmed-article:1971256 | pubmed:abstractText | Incubation of human platelets with the hemolysin-producing Escherichia coli strain K-12 (pANN5211) induced the activation of protein kinase C, aggregation of platelets, calcium influx, low amounts of 12-hydroxyeicosatetraenoic acid (12-HETE), and release of serotonin from dense granules. Nonhemolytic isogenic strains of E. coli 536/21 which differed only in their types of adhesins (MSH+ MS-Fim+; S-MRH+ S-Fim+; P-MRH+ P-Fim+) released neither serotonin nor 12-HETE from human platelets nor induced platelet aggregation. All hemolysin-negative bacteria except E. coli 536/21, without any adhesins, were able to activate protein kinase C reversibly but did not induce calcium influx. Activation of platelets with fluoride, an activator of the GTP-binding protein, was associated with protein kinase C activation, calcium influx, platelet aggregation, serotonin release, and 12-HETE formation. The simultaneous stimulation of platelets with NaF and the nonhemolytic E. coli strains suppressed several of the NaF-induced platelet responses. Membrane preparations isolated from stimulated platelets with hemolysin-negative and hemolysin-positive E. coli showed increased binding of guanylylimidodiphosphate, a nonhydrolyzable GTP analog, and enhanced GTPase activity. | lld:pubmed |
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| pubmed-article:1971256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1971256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1971256 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1971256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1971256 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1971256 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1971256 | pubmed:author | pubmed-author:KönigWW | lld:pubmed |
| pubmed-article:1971256 | pubmed:author | pubmed-author:SchefferJJ | lld:pubmed |
| pubmed-article:1971256 | pubmed:author | pubmed-author:KönigBB | lld:pubmed |
| pubmed-article:1971256 | pubmed:author | pubmed-author:SchönfeldWW | lld:pubmed |
| pubmed-article:1971256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1971256 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:1971256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1971256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1971256 | pubmed:pagination | 1591-9 | lld:pubmed |
| pubmed-article:1971256 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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