| pubmed-article:19710692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1335234 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1705358 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0021920 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1425745 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1705357 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1420137 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19710692 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:19710692 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19710692 | pubmed:dateCreated | 2010-1-20 | lld:pubmed |
| pubmed-article:19710692 | pubmed:abstractText | Programmed death-1 ligand 2 (PD-L2) expression extends beyond macrophages/dendritic cells to B-1 B cells, a distinct B-cell lineage that is responsible for natural immunoglobulin and which is repertoire skewed toward autoreactive specificities. PD-L2 expression is constitutive in B-1 cells, whereas it is inducible in other cell types, suggesting that PD-L2 is regulated differently in the former versus the latter, and this proved to be the case, both in transcription and promotion. B-1 cells express a PD-L2 transcript that lacks exon 1, in contrast to macrophages/dendritic cells for which exon1 is included, reflecting a unique start site upstream of exon 2. PD-L2 transcription in B-1 cells is regulated by a novel intronic promoter located between exons 1 and 2. This intronic promoter binds Octamer binding protein 1 (Oct1) and Oct2, and although these transcription factors are present in all B cells, Oct2 binding is found in vivo only in B-1 cells and not PD-L2-negative B-2 cells. Moreover, the proximal promoter upstream of exon 1 that is active in macrophages is inactive in B-1 cells. Thus, PD-L2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of Oct1 and Oct2 binding. | lld:pubmed |
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| pubmed-article:19710692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19710692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19710692 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19710692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19710692 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19710692 | pubmed:issn | 1476-5470 | lld:pubmed |
| pubmed-article:19710692 | pubmed:author | pubmed-author:RothsteinT... | lld:pubmed |
| pubmed-article:19710692 | pubmed:author | pubmed-author:KakuHH | lld:pubmed |
| pubmed-article:19710692 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19710692 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:19710692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19710692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19710692 | pubmed:pagination | 55-66 | lld:pubmed |
| pubmed-article:19710692 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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