| pubmed-article:19707331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C1622572 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:19707331 | lifeskim:mentions | umls-concept:C1619962 | lld:lifeskim |
| pubmed-article:19707331 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19707331 | pubmed:dateCreated | 2009-8-26 | lld:pubmed |
| pubmed-article:19707331 | pubmed:abstractText | The development of immunosuppressive drugs has in recent years been focused on prevention of acute rejection. This has led to an increase in one-year allograft survival. However, these drugs have non-immune effects which contribute to the high incidence of late graft loss, as a consequence of chronic allograft nephropathy, and the death of patients. As an immune-specific alternative to conventional immunosuppressants, new biotechnology tools have been developed; they target the costimulation signal of T-cell activation, particularly by the "classical" B7/CD28 and CD40/CD40L pathways. Here, we review the limitations of current immunosuppressive protocols, the benefits of classical B7/CD28 costimulation blockade, and the first large-scale clinical application of this strategy to human transplantation with belatacept. We will also consider novel costimulatory molecules of the B7/CD28 and TNF/TNF-R families, which appear to be important for the functions of memory and effector T-cells. | lld:pubmed |
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| pubmed-article:19707331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19707331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19707331 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:19707331 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19707331 | pubmed:issn | 1177-5475 | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:CharpentierBe... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:DürrbachAntoi... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:BeaudreuilSév... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:CréputCarolin... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:FrançoisHélèn... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:SnanoudjRenau... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:DeroureBenjam... | lld:pubmed |
| pubmed-article:19707331 | pubmed:author | pubmed-author:FrangiéCarlos... | lld:pubmed |
| pubmed-article:19707331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19707331 | pubmed:volume | 1 | lld:pubmed |
