| pubmed-article:19703973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C0318248 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19703973 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19703973 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19703973 | pubmed:dateCreated | 2009-10-19 | lld:pubmed |
| pubmed-article:19703973 | pubmed:abstractText | Vibrio cholerae O1 can cause diarrheal disease that may be life-threatening without treatment. Natural infection results in long-lasting protective immunity, but the role of T cells in this immune response has not been well characterized. In contrast, robust B-cell responses to V. cholerae infection have been observed. In particular, memory B-cell responses to T-cell-dependent antigens persist for at least 1 year, whereas responses to lipopolysaccharide, a T-cell-independent antigen, wane more rapidly after infection. We hypothesize that protective immunity is mediated by anamnestic responses of memory B cells in the gut-associated lymphoid tissue, and T-cell responses may be required to generate and maintain durable memory B-cell responses. In this study, we examined B- and T-cell responses in patients with severe V. cholerae infection. Using the flow cytometric assay of the specific cell-mediated immune response in activated whole blood, we measured antigen-specific T-cell responses using V. cholerae antigens, including the toxin-coregulated pilus (TcpA), a V. cholerae membrane preparation, and the V. cholerae cytolysin/hemolysin (VCC) protein. Our results show that memory T-cell responses develop by day 7 after infection, a time prior to and concurrent with the development of B-cell responses. This suggests that T-cell responses to V. cholerae antigens may be important for the generation and stability of memory B-cell responses. The T-cell proliferative response to VCC was of a higher magnitude than responses observed to other V. cholerae antigens. | lld:pubmed |
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| pubmed-article:19703973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19703973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19703973 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19703973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19703973 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19703973 | pubmed:issn | 1098-5522 | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:BouchéBB | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:ParkerKenneth... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:CalderwoodSte... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:QadriFirdausi... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:WeilAna AAA | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:RyanEdward... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:ArifuzzamanMo... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:BanerjeeKalya... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:LaRocqueRegin... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:KhanAshraful... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:ChowdhuryFahi... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:BhuiyanTaufiq... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:SheikhAlaulla... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:HarrisAaron... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:MurshedFarhan... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:HossainAzimA | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:KendallEmily... | lld:pubmed |
| pubmed-article:19703973 | pubmed:author | pubmed-author:TariqueAbdull... | lld:pubmed |
| pubmed-article:19703973 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19703973 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:19703973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19703973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19703973 | pubmed:pagination | 5090-6 | lld:pubmed |
