| pubmed-article:19702757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0085245 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0015689 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19702757 | lifeskim:mentions | umls-concept:C0075197 | lld:lifeskim |
| pubmed-article:19702757 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19702757 | pubmed:dateCreated | 2009-8-25 | lld:pubmed |
| pubmed-article:19702757 | pubmed:abstractText | Dietary omega-3 polyunsaturated fatty acids have a proven role in reducing the risk of cardiovascular disease and precursor disease states such as metabolic syndrome. Although most studies have focussed on the predominant omega-3 fatty acids found in fish oils (eicosapentaenoic acid and docosahexaenoic acid), recent evidence suggests similar health benefits from their common precursor, stearidonic acid. Stearidonic acid is a Delta6-unsaturated C18 omega-3 fatty acid present in a few plant species (mainly the Boraginaceae and Primulaceae) reflecting the general absence of Delta6-desaturation from higher plants. Using a Delta6-desaturase from Primula vialii, we generated transgenic Arabidopsis and linseed lines accumulating stearidonic acid in their seed lipids. Significantly, the P. vialiiDelta6-desaturase specifically only utilises alpha-linolenic acid as a substrate, resulting in the accumulation of stearidonic acid but not omega-6 gamma-linolenic acid. Detailed lipid analysis revealed the accumulation of stearidonic acid in neutral lipids such as triacylglycerol but an absence from the acyl-CoA pool. In the case of linseed, the achieved levels of stearidonic acid (13.4% of triacylglycerols) are very similar to those found in the sole natural commercial plant source (Echium spp.) or transgenic soybean oil. However, both those latter oils contain gamma-linolenic acid, which is not normally present in fish oils and considered undesirable for heart-healthy applications. By contrast, the stearidonic acid-enriched linseed oil is essentially devoid of this fatty acid. Moreover, the overall omega-3/omega-6 ratio for this modified linseed oil is also significantly higher. Thus, this nutritionally enhanced linseed oil may have superior health-beneficial properties. | lld:pubmed |
| pubmed-article:19702757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19702757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19702757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19702757 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19702757 | pubmed:issn | 1467-7652 | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:GrahamIan AIA | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:NapierJohnath... | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:SayanovaOlgaO | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:HaslamRichard... | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:LarsonTony... | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:Venegas-Caler... | lld:pubmed |
| pubmed-article:19702757 | pubmed:author | pubmed-author:Ruiz-LópezNoe... | lld:pubmed |
| pubmed-article:19702757 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19702757 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:19702757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19702757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19702757 | pubmed:pagination | 704-16 | lld:pubmed |
| pubmed-article:19702757 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:meshHeading | pubmed-meshheading:19702757... | lld:pubmed |
| pubmed-article:19702757 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19702757 | pubmed:articleTitle | The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. | lld:pubmed |
| pubmed-article:19702757 | pubmed:affiliation | Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts, UK. | lld:pubmed |
| pubmed-article:19702757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19702757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19702757 | lld:pubmed |
