| pubmed-article:19689397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:19689397 | lifeskim:mentions | umls-concept:C0045330 | lld:lifeskim |
| pubmed-article:19689397 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19689397 | pubmed:dateCreated | 2009-8-19 | lld:pubmed |
| pubmed-article:19689397 | pubmed:abstractText | Triiodobenzoic acid (TIBA) represents the core structure of most clinically used contrast agents for computed tomography and other X-ray procedures. To construct an intracellular radiopaque contrast agent, TIBA was coupled to various different positively and negatively charged fluorescein iothiocyanate (FITC)-labelled peptides. TIBA coupled to the SV40 T Antigen nuclear localization sequence (NLS) stained 80% of human glioma cells and caused cell death. This occurred with C- or N-terminal binding of TIBA and with the correct or mutant NLS. No cell death and only small numbers of stained cells (below 3 %) were observed after incubation with NLS conjugates lacking TIBA or after incubation with TIBA-conjugates containing a negatively charged polyglutamic acid stretch. TIBA-conjugates containing the Antennapedia-derived cell-penetrating peptide penetratin were only nuclearly taken up when TIBA and FITC were coupled to lysines outside the 16-amino acid peptide sequence. The study shows that intracellular TIBA may have potential as a chemotherapeutic agent rather than a contrast agent. | lld:pubmed |
| pubmed-article:19689397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19689397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19689397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19689397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19689397 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19689397 | pubmed:issn | 1875-6638 | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:VogelUlrichU | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:EchnerHartmut... | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:KalbacherHube... | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:HecklStefanS | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:BeckAlexander... | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:GharabaghiAli... | lld:pubmed |
| pubmed-article:19689397 | pubmed:author | pubmed-author:SturzuAlexand... | lld:pubmed |
| pubmed-article:19689397 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19689397 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:19689397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19689397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19689397 | pubmed:pagination | 385-91 | lld:pubmed |
| pubmed-article:19689397 | pubmed:meshHeading | pubmed-meshheading:19689397... | lld:pubmed |
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| pubmed-article:19689397 | pubmed:meshHeading | pubmed-meshheading:19689397... | lld:pubmed |
| pubmed-article:19689397 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19689397 | pubmed:articleTitle | Cell nucleus directed 2,3,5-triiodobenzoic acid conjugates. | lld:pubmed |
| pubmed-article:19689397 | pubmed:affiliation | Department of Neuroradiology; University of Tübingen; Hoppe-Seyler-Str.3; 72076 Tübingen, Germany. | lld:pubmed |
| pubmed-article:19689397 | pubmed:publicationType | Journal Article | lld:pubmed |
