| pubmed-article:1968837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0085246 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C1512942 | lld:lifeskim |
| pubmed-article:1968837 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1968837 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1968837 | pubmed:dateCreated | 1990-4-23 | lld:pubmed |
| pubmed-article:1968837 | pubmed:abstractText | This study was carried out to determine the exact phenotype of intraepithelial lymphocytes (IEL) in euthymic and athymic nude mice. The phenotype of IEL in euthymic and athymic mice is mainly CD3+CD8+. However, based on Thy-1- and CD3-associated receptor expression we can subdivide the CD3CD8 population into different subpopulations in euthymic and athymic mice. In euthymic and athymic mice several CD3CD8 populations can be defined. One population expressing Thy-1 and the T cell receptor (TcR) alpha beta is absent in athymic mice. Two other CD3+CD8+ populations can be detected in euthymic and athymic mice. Based on Northern blot and flow cytometric analysis we have to conclude that these populations express the CD3-associated TcR gamma delta. One of the TcR gamma delta-expressing populations also expresses Thy-1 at low surface density. This is in contrast to the CD3CD8 population expressing the TcR alpha beta, which expresses Thy-1 at high surface density. There are also, however, especially in athymic nude mice, significant numbers of CD3-CD8+ cells present with the same localization as IEL. The function of these cells is yet unknown. Using a probe for the delta chain we have shown that IEL preferentially express 2-kb mRNA, while nearly no delta chain 1.7-kb mRNA is expressed by these cells. This is in contrast to delta mRNA in thymocytes. Equal quantities of the 1.7- and 2.0-kb delta chain mRNA species were found in RNA isolated from thymocytes. The results imply that CD3+CD8+ intestinal IEL expressing the CD3-associated TcR gamma delta can differentiate in absence of the thymus and represent a thymus-independent lineage of cells bearing this receptor. | lld:pubmed |
| pubmed-article:1968837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1968837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1968837 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1968837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1968837 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1968837 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:CooleyLL | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:RozingJJ | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:De GeusBB | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:NagelkerkenLL | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:Van den... | lld:pubmed |
| pubmed-article:1968837 | pubmed:author | pubmed-author:Van der... | lld:pubmed |
| pubmed-article:1968837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1968837 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1968837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1968837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1968837 | pubmed:pagination | 291-8 | lld:pubmed |
| pubmed-article:1968837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1968837 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1968837 | pubmed:articleTitle | Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated gamma delta T cell receptor. | lld:pubmed |
| pubmed-article:1968837 | pubmed:affiliation | Department of Immunology, TNO Institute of Experimental Gerontology, Rijswijk, The Netherlands. | lld:pubmed |
| pubmed-article:1968837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1968837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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