| pubmed-article:1968230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C1179149 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0439640 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:1968230 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:1968230 | pubmed:issue | 6261 | lld:pubmed |
| pubmed-article:1968230 | pubmed:dateCreated | 1990-3-19 | lld:pubmed |
| pubmed-article:1968230 | pubmed:abstractText | The skin of mice contains dendritic epidermal cells carrying the Thy-1 antigen (Thy-1+ dEC) which express antigen receptors composed of the T-cell antigen receptor (TCR) gamma- and delta-chains. Although the role of the thymus in the generation of most T cells is well established, the involvement of the thymus in the generation of Thy-1+ dEC is not clear. Because bone marrow cells can give rise in Thy-1+ dEC in chimaeric mice and Thy-1+ dEC are detected in the skin of athymic nude nice, it has been proposed that Thy-1+ dEC arise continuously from bone marrow precursors by a thymus-independent mechanism. But it has recently been determined that Thy-1+ dEC in nude mice do not express TCR at the cell surface, and that the gamma- and delta-chain genes are in germ-line configuration, leaving the role of the thymus in the generation of Thy-1+ dEC uncertain. Most Thy-1+ dEC in all normal mouse strains examined express TCR containing the V gamma 3 gene product. This V gene segment is expressed on the first wave of TCR-expressing cells to emerge during fetal development, and in adult mice is detectable only on cells in the epidermis. In addition to use of this 'fetal' V gamma segment, other features of the Thy-1+ dEC TCR genes, including absence or minimal presence of nongerm-line-encoded nucleotides at the junctions and use of a single D element in the rearranged delta-chain gene are typical of rearrangements found in fetal, and not adult, thymus. Here we demonstrate that precursors that are present only in the fetal thymus give rise to Thy-1+ dEC in the skin of adult mice. | lld:pubmed |
| pubmed-article:1968230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1968230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1968230 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1968230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1968230 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1968230 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1968230 | pubmed:author | pubmed-author:AllisonJ PJP | lld:pubmed |
| pubmed-article:1968230 | pubmed:author | pubmed-author:HavranW LWL | lld:pubmed |
| pubmed-article:1968230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1968230 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1968230 | pubmed:volume | 344 | lld:pubmed |
| pubmed-article:1968230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1968230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1968230 | pubmed:pagination | 68-70 | lld:pubmed |
| pubmed-article:1968230 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1968230 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1968230 | pubmed:articleTitle | Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors. | lld:pubmed |
| pubmed-article:1968230 | pubmed:affiliation | Cancer Research Laboratory, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:1968230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1968230 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1968230 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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